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Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Potential Cancer Therapeutic Agents
Microtubules play an important structural role in the endothelial cells lining tumor vasculature. This vasculature is distinct from that of healthy cells and characterized as immature and chaotic, making it an attractive ... -
Design, synthesis, and biological evaluation of tumor-selective vascular disrupting agents, water-soluble amino acid prodrug conjugates, and bioreductively activatable prodrug conjugates targeting tumor hypoxia.
(2015-11-10)Selective targeting of tumor cells in comparison to healthy cells is vital in order to increase drug efficacy and reduce side effects to cancer patients. The underlying morphological and physiological differences between ... -
Design, synthesis, biochemical and biological evaluation of benzocyclic and enediyne analogs of combretastatins as potential tubulin binding ligands in the treatment of cancer.
(2008-03-03)One out of four deaths per day in the United States will be caused by cancer in the year 2007. Cancer still remains the second major cause of mortality both in developed as well as developing countries. Small molecule ... -
Designing a Capstone Course to Simulate the Industrial Environment
(2009-10-26)The creation of a capstone course for an un- dergraduate computer science curriculum mirrors traditional software design. Initially, a high-level goal is created. This is refined into lower-level specifications by ... -
Designing a gallery and then some : experiences as an exhibits intern at the Dr Pepper Museum and Free Enterprise Institute.
This internship presentation details the author’s experience as an intern in the Exhibit/Interpretation Department at the Dr Pepper Museum and Free Enterprise Institute in Waco, Texas during the summer of 2014. As an intern ... -
Designing a wilderness : the legacy of Benton MacKaye and the Appalachian Trail.
(, 2012-08-08)Forester and regional planner Benton MacKaye first published a plan for a long-distance hiking trail along the crest of the Appalachian Mountains in 1921. Ninety years later, MacKaye's greatest accomplishment is the ... -
Designing incentives in P2P systems.
(, 2013-09-24)The goal of this thesis is bringing closer together the game theoretic approach of creating incentives with the requirements and properties of P2P systems. Briefly, we detail the P2P system context that incentive mechanisms ... -
Designing quantitative structure activity relationships (QSAR) to predict specific toxic endpoints for polybrominated diphenyl ethers (PBDE) in mammalian cell culture systems.
(, 2011-12-19)Polybrominated diphenyl ethers (PBDEs) are becoming increasingly known as effective flame retardants and have vast industrial application in products like plastics, building materials, and textiles. They are found to be ... -
Designing, constructing, and testing a second-generation prototype mechanical hippotherapy horse.
(, 2011-09-14)The use of horses as a means of therapy has been documented for some time. To determine why this type of therapy works and to provide a means of expanding its accessibility, a mechanical horse has been developed. Data ... -
Desire versus conscience : development of the id and the ego in Ian McEwan's fiction.
(2009-08-26)Throughout the course of McEwan's writing career, his books have dealt with interpersonal relationships, society, history, and the human condition, but his later works have grown and become more introspective, less shocking, ... -
Detailed paleoclimatic records from late Pennsylvanian polygenetic paleosols : north-central Texas, USA.
(, 2013-09-24)Two Canyon Group (late-Pennsylvanian, Missourian) multistory, polygenetic paleosol intervals in north-central Texas, USA record complex paleoclimatic and paleohydrologic histories. Both paleosol intervals show evidence for ... -
The determinants of Chinese housing price inflation.
(, 2013-05-15)Housing prices in major Chinese cities have been soaring since 2003. Some economists believe that this represents a dangerous speculative bubble while others argue that Chinese housing price inflation is a normal consequence ... -
Determinants of faculty salaries at elite liberal arts colleges.
(2011-01-05)In this paper we focus on the determinants of faculty salary levels at elite liberal arts colleges for specific years over the past decade. We address the role regional personal income per capita and endowment play in ... -
Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
(2014-12-03)T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations ... -
Determination of pharmaceuticals and personal care products in fish using high performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry.
(Washington, DC : American Chemical Society Publications., 2007)Labeled as emerging organic contaminants, pharmaceuticals and personal care products (PPCPs) have been the focus of global environmental research for over a decade. PPCPs have caused widespread concern due to their extensive ... -
Determination of pharmaceuticals in fish and wastewater using isotope dilution high performance liquid chromatography-tandem mass spectrometry.
(2009-07-01)A method has been developed for the trace analysis of 15 pharmaceuticals and employs liquid chromatography/tandem mass spectrometry (LC-ESI-MS/MS). Unlike many previous methods, which suffer from matrix suppression and ... -
Determination of planktonic metabolism and trophic status in Texas shallow ponds
(2014-04-29)Potential daily aerial rates of plankton production and respiration for twenty-seven shallow ponds within the Bullhide Creek watershed between January and March 2013 were determined. Photosynthetic parameters were estimated ... -
Determination of the levitation limits of dust particles within the sheath in complex plasma experiments
(Physics of Plasmas, 2012-01-23)Experiments are performed in which dust particles are levitated at varying heights above the powered electrode in a radio frequency plasma discharge by changing the discharge power. The trajectories of particles dropped ... -
Determining related work-to-rest ratios following a maximal effort isokinetic leg extension bout in trained and untrained males : a double-blind creatine/placebo controlled study.
(2010-02-02)Purpose: A single 30 second bout of high intensity isokinetic exercise is capable of depleting available skeletal muscle Phosphocreatine (PCr) and adenosine triphosphate (ATP). Within several minutes the body is able to ... -
Determining the complex permittivity of materials with the Waveguide-Cutoff method.
(2006-07-31)A new method for the determination of complex permittivity values is explained. The Waveguide-Cutoff method consists of a rectangular chamber with loop antennas for excitation from a Vector Network Analyzer. It then ...