Browsing by Title
Now showing items 620-639 of 2831
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Design and synthesis of combretastatin A-1 analogs, small molecule vascular disrupting agents, and bioreductive triggers as potential therapeutic agents for the treatment of cancer.
(2011-01-05)Cancer is the second leading cause of death in the United States with over 550,000 deaths in 2009 and a devastating 7.9 million deaths worldwide in 2007. Vascular disrupting agents (VDAs) represent a novel method developed ... -
Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
(2007-03-08)Cancer remains a deadly affliction for millions across the United States, and the number of new cases is only expected to rise in the years to come. In the field of anticancer research, vascular disrupting agents (VDAs) ... -
Design and synthesis of functionalized small-molecule inhibitors of cathepsins L and K.
(, 2012-08-08)Inhibition of a class of cysteine proteases known as the cathepsins has received increasing attention in recent years, since these enzymes play key roles in cancer metastasis. Cathepsins B, K, and L have been of particular ... -
Design and Synthesis of Functionalized Thiosemicarbazone Analogues as Potential Anti-metastatic Agents
(2013-05-24)Metastasis is often the ultimate cause of death among cancer patients. An emerging target in the treatment of metastasis is cathepsin L which facilitates the degradation of the extracellular matrix thereby providing a ... -
Design and synthesis of non-peptidic thiosemicarbazone derivatives as inhibitors of cathepsins L and K.
(2012-11-29)Cathepsin L, a member of the lysosome cysteine proteases, is ubiquitously expressed in tissue and is responsible for protein turnover. An overexpression of cathepsin L by certain tumor types is associated with enhanced ... -
Design and Synthesis of Novel Vascular Disrupting Agents With Potential Chemotherapeutic Properties
(2013-05-23)The term cancer is a widely universal label for a cluster of cells that can divide uncontrollably and invade the surrounding healthy tissue. Vascular targeting agents (VTAs) represent an important and emerging area of ... -
Design and synthesis of novel β-cyclodextrins and their application as chiral stationary phases for gas chromatography.
(2011-01-05)Enantiomers can be directly separated only with use of systems containing a chiral selector. Cyclodextrins (CDs) and modified cyclodextrins have been used as chiral selectors for their ability to form host-guest complexes ... -
Design and synthesis of potential serotonin-selective reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors for the treatment of depression.
(2010-10-08)Depression is a common disease characterized by feelings of deep sadness, guiltiness, loss of interest in once pleasurable activities, and thoughts of self-harm among others. Affecting an estimated 121 million people ... -
The Design and Synthesis of Small-Molecule Anticancer Agents Targeted Through Antibody-Drug Conjugates
(2014-05-01)A relatively recent addition to the arsenal of potential treatments for cancer involves the use of vascular disrupting agents (VDAs). Small-molecule VDAs target the blood supply of a tumor, starving it of nutrients and ... -
Design and synthesis of small-molecule inhibitors of cathepsin L bearing the thiosemicarbazone warhead as potential anti-metastatic agents.
(2015-11-18)Mestastasis is a devastating component associated with tumor progression which claims the majority of lives lost to cancer. Upregulation of cathepsin L, a powerful cysteine protease capable of degrading components in the ... -
Design and Synthesis of Vascular Disrupting Agents that Bear the Indole Molecular Framework
(2016-08-09)The discovery of colchicine and combretastatin A-4 (CA4), two naturally occurring compounds that inhibit tubulin polymerization, have spurred great interest in small-molecule anticancer agents that interact with the ... -
Design and validation of a solar domestic hot water heating simulator.
(2009-07-08)A growing demand for emerging alternative energy technologies is fueled by rising energy prices and decreasing energy supplies. Domestic hot water heating is an industry that continues to benefit from increased research ... -
The design and validation of an impinging jet test facility.
(2006-05-28)An experimental jet impingement facility was constructed with the capability of conducting a detailed analysis of the local heat transfer coefficients beneath an array of large impinging jets. The facility was validated ... -
Design and validation of new testing apparatus for testing helical compression springs under combined axial, shear, torsion, and bending loads.
(, 2011-09-14)Helical compression springs are normally used to provide a linear force response to compressive displacement. However, compression springs can be used to provide lateral force and rotational torque responses to lateral and ... -
Design of a microwave sensor for non-invasive determination of blood-glucose concentration.
(2006-05-27)Diabetes is a disease that afflicts millions worldwide. To control the effects of this disease, diabetics must check their blood glucose levels on a regular basis. Currently, all daily glucose monitoring techniques are ... -
Design of a solar thermal collector simulator.
(2009-06-02)The recent increased interest in renewable energy has created a need for research in the area of solar technology. This has brought about many new opportunities for universities and research centers to build upon existing ... -
Design of an experimental arrangement for the detection of neutral fragments produced in electron molecule collisions.
(, 2014-09-05)Existing experimental and theoretical values of the production cross sections of neutral fragments of electron and methane (CH₄) collision have been studied. Possible neutral production cross sections of CH₄ are estimated ... -
Design, analysis and simulation of a new current controller for wind power generation system using proportional plus resonance control.
(, 2011-09-14)This thesis presents design, analysis and simulation of a new current control scheme for wind power generation system (WPGS). Proportional plus resonance (PR) controller is proposed to improve the accuracy of the control ... -
Design, optimization, and evaluation of conditionally active gene therapy vectors.
(2008-06-09)It is the objective of this project to produce gene therapy vectors that are active and/or significantly up-regulated due to specific physiological conditions. The significance of such constructs is that it imparts a greater ... -
Design, synthesis and biological evaluation of new anti-Cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of Chagas.
(2006-05-29)In an effort to combat cancer, the development of a relatively new type of anti-cancer drugs known as vascular disrupting agents (VDAs) seems to be a promising clinical approach. VDAs selectively interfere with blood flow ...