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Now showing items 680-699 of 3015
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Design and validation of new testing apparatus for testing helical compression springs under combined axial, shear, torsion, and bending loads.
(, 2011-09-14)Helical compression springs are normally used to provide a linear force response to compressive displacement. However, compression springs can be used to provide lateral force and rotational torque responses to lateral and ... -
Design of a microwave sensor for non-invasive determination of blood-glucose concentration.
(2006-05-27)Diabetes is a disease that afflicts millions worldwide. To control the effects of this disease, diabetics must check their blood glucose levels on a regular basis. Currently, all daily glucose monitoring techniques are ... -
Design of a solar thermal collector simulator.
(2009-06-02)The recent increased interest in renewable energy has created a need for research in the area of solar technology. This has brought about many new opportunities for universities and research centers to build upon existing ... -
Design of an experimental arrangement for the detection of neutral fragments produced in electron molecule collisions.
(, 2014-09-05)Existing experimental and theoretical values of the production cross sections of neutral fragments of electron and methane (CH₄) collision have been studied. Possible neutral production cross sections of CH₄ are estimated ... -
Design, analysis and simulation of a new current controller for wind power generation system using proportional plus resonance control.
(, 2011-09-14)This thesis presents design, analysis and simulation of a new current control scheme for wind power generation system (WPGS). Proportional plus resonance (PR) controller is proposed to improve the accuracy of the control ... -
Design, optimization, and evaluation of conditionally active gene therapy vectors.
(2008-06-09)It is the objective of this project to produce gene therapy vectors that are active and/or significantly up-regulated due to specific physiological conditions. The significance of such constructs is that it imparts a greater ... -
Design, synthesis and biological evaluation of new anti-Cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of Chagas.
(2006-05-29)In an effort to combat cancer, the development of a relatively new type of anti-cancer drugs known as vascular disrupting agents (VDAs) seems to be a promising clinical approach. VDAs selectively interfere with blood flow ... -
Design, synthesis and biological evaluation of novel serotonin reuptake inhibitors and novel derivatives of a nitrogen-containing combretastatin analog.
(2006-10-13)Depression is a common and serious illness that affects one out of every ten Americans each year. Since the 1980's, selective serotonin reuptake inhibitors (SSRIs) have been the pharmaceuticals of choice for the treatment ... -
Design, synthesis and evaluation of di-nitrogen derivatives of combretastatin and novel cruzain inhibiting compounds for the treatment of Chagas disease.
(2008-03-03)Over the past years cancer statistics have continued to rise to the point that the World Health Organization said that in 2005 cancer was leading cause of death worldwide. Years of research have resulted in many new ... -
The design, synthesis, and biological evaluation of indole-based anticancer agents.
(, 2014-01-28)Solid tumors depend on a vascular network that delivers nutrients and oxygen, thus selectively targeting the developed tumor vasculature represents a feasible strategy for the treatment of cancer. Both small-molecules and ... -
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF INDOLE-BASED VASCULAR DISRUPTING AGENTS FOR THE POTENTIAL TREATMENT OF CANCER
(2012-05-02)An established strategy in therapeutic oncology entails selectively targeting the tubulin-microtubule system, resulting in inhibition or hyperstimulation of tubulin polymerization effecting cell cycle arrest at anaphase. ... -
Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Potential Cancer Therapeutic Agents
Microtubules play an important structural role in the endothelial cells lining tumor vasculature. This vasculature is distinct from that of healthy cells and characterized as immature and chaotic, making it an attractive ... -
Design, synthesis, and biological evaluation of tumor-selective vascular disrupting agents, water-soluble amino acid prodrug conjugates, and bioreductively activatable prodrug conjugates targeting tumor hypoxia.
(2015-11-10)Selective targeting of tumor cells in comparison to healthy cells is vital in order to increase drug efficacy and reduce side effects to cancer patients. The underlying morphological and physiological differences between ... -
Design, synthesis, biochemical and biological evaluation of benzocyclic and enediyne analogs of combretastatins as potential tubulin binding ligands in the treatment of cancer.
(2008-03-03)One out of four deaths per day in the United States will be caused by cancer in the year 2007. Cancer still remains the second major cause of mortality both in developed as well as developing countries. Small molecule ... -
Designing a Capstone Course to Simulate the Industrial Environment
(2009-10-26)The creation of a capstone course for an un- dergraduate computer science curriculum mirrors traditional software design. Initially, a high-level goal is created. This is refined into lower-level specifications by ... -
Designing a gallery and then some : experiences as an exhibits intern at the Dr Pepper Museum and Free Enterprise Institute.
This internship presentation details the author’s experience as an intern in the Exhibit/Interpretation Department at the Dr Pepper Museum and Free Enterprise Institute in Waco, Texas during the summer of 2014. As an intern ... -
Designing a wilderness : the legacy of Benton MacKaye and the Appalachian Trail.
(, 2012-08-08)Forester and regional planner Benton MacKaye first published a plan for a long-distance hiking trail along the crest of the Appalachian Mountains in 1921. Ninety years later, MacKaye's greatest accomplishment is the ... -
Designing incentives in P2P systems.
(, 2013-09-24)The goal of this thesis is bringing closer together the game theoretic approach of creating incentives with the requirements and properties of P2P systems. Briefly, we detail the P2P system context that incentive mechanisms ... -
Designing quantitative structure activity relationships (QSAR) to predict specific toxic endpoints for polybrominated diphenyl ethers (PBDE) in mammalian cell culture systems.
(, 2011-12-19)Polybrominated diphenyl ethers (PBDEs) are becoming increasingly known as effective flame retardants and have vast industrial application in products like plastics, building materials, and textiles. They are found to be ... -
Designing, constructing, and testing a second-generation prototype mechanical hippotherapy horse.
(, 2011-09-14)The use of horses as a means of therapy has been documented for some time. To determine why this type of therapy works and to provide a means of expanding its accessibility, a mechanical horse has been developed. Data ...