Browsing College of Arts and Sciences by Author "Kane, Robert R."
Now showing items 1-6 of 6
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Discovery of DNA-enzymes dependent on small-molecule cofactors; design, synthesis and evaluation of TLR-7 agonists and their immunoprotein conjugates.
Romero, José Roberto Boquín. (2010-10-08)Several catalytic families of DNA enzymes (deoxyribozymes) have previously been isolated through the use of an in vitro selection technique in our laboratory. The activities of these deoxyribozymes appear to be dependent ... -
Meniscal tissue bonding and exploration of sonochemical tissue modification.
Dean, Drew W. (2009-04-01)The goal of the primary project was to explore further means of meniscal repair through application of the immobilization techniques previously developed by our research group. The menisci are susceptible to tears due to ... -
Modification of fresh tissue surfaces; synthesis of labeled L-dopa analogs; and synthesis of metoclopramide analogs.
Perera, Aruna B. (2006-05-27)One of the main goals of the primary project was to develop methods to site specifically immobilize functional proteins on a tissue surface. There are many examples of proteins that have been chemically modified and ... -
Photochemical modification of proteins and tissue surface using 1,8-naphthalimides : DNA enzyme cofactors.
Uzcátegui, Gabriela. (2010-10-08)Our lab has long had an interest in the potential biomedical applications of naphthalimide photochemistry, including especially the use for the bonding and modification of fresh tissue. Photochemical tissue bonding represents ... -
Synthesis of modulators of TLR2, TLR4, and TLR7 functionalized for conjugation to biomolecules.
Akinbobuyi, Babatope. 1979- (2016-11-09)A wide range of pathogen-associated molecules including acylated lipopeptides, lipopolysaccharides (LPS), and single-stranded viral RNAs initiate an innate immune response via binding to members of a protein family called ... -
Synthetic coenzymes for in vitro selection of DNA enzymes.
Carranza, Dorn L. (2007-01-22)Over the past 10 years a number of catalytically active single-stranded DNA molecules (deoxyribozymes) have been isolated from combinatorial libraries (pools) of randomized oligonucleotides. These enzyme-like DNAs customarily ...