Browsing Theses/Dissertations - Chemistry & Biochemistry by Title
Now showing items 16-35 of 67
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Design, synthesis and biological evaluation of novel serotonin reuptake inhibitors and novel derivatives of a nitrogen-containing combretastatin analog.
(2006-10-13)Depression is a common and serious illness that affects one out of every ten Americans each year. Since the 1980's, selective serotonin reuptake inhibitors (SSRIs) have been the pharmaceuticals of choice for the treatment ... -
Design, synthesis and evaluation of di-nitrogen derivatives of combretastatin and novel cruzain inhibiting compounds for the treatment of Chagas disease.
(2008-03-03)Over the past years cancer statistics have continued to rise to the point that the World Health Organization said that in 2005 cancer was leading cause of death worldwide. Years of research have resulted in many new ... -
The design, synthesis, and biological evaluation of indole-based anticancer agents.
(, 2014-01-28)Solid tumors depend on a vascular network that delivers nutrients and oxygen, thus selectively targeting the developed tumor vasculature represents a feasible strategy for the treatment of cancer. Both small-molecules and ... -
Design, synthesis, biochemical and biological evaluation of benzocyclic and enediyne analogs of combretastatins as potential tubulin binding ligands in the treatment of cancer.
(2008-03-03)One out of four deaths per day in the United States will be caused by cancer in the year 2007. Cancer still remains the second major cause of mortality both in developed as well as developing countries. Small molecule ... -
Determination of pharmaceuticals and personal care products in fish using high performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry.
(Washington, DC : American Chemical Society Publications., 2007)Labeled as emerging organic contaminants, pharmaceuticals and personal care products (PPCPs) have been the focus of global environmental research for over a decade. PPCPs have caused widespread concern due to their extensive ... -
Discovery and development of unique small molecule chromene based ligands and combretastatin analogs as potential second generation vascular disrupting agents towards cancer chemotherapy.
(2006-05-29)Cancer is a devastating disease, which remains one of the leading causes of death worldwide. In our continuing quest to help find a cure for cancer, we have discovered and developed new small molecule vascular disrupting ... -
Discovery of a novel adenosine 5'-phosphosulfate (APS) reductase from the methanarcheon Methanocaldococcus jannaschii.
(Elsevier, 2010-12)This thesis presents the first discovery of adenosine 5'-phosphosulfate reductase (APR), a key enzyme of the sulfate reduction pathway, in the methanarchaeon Methanocaldococcus jannaschii. While the sulfate reduction pathway ... -
Discovery of DNA-enzymes dependent on small-molecule cofactors; design, synthesis and evaluation of TLR-7 agonists and their immunoprotein conjugates.
(2010-10-08)Several catalytic families of DNA enzymes (deoxyribozymes) have previously been isolated through the use of an in vitro selection technique in our laboratory. The activities of these deoxyribozymes appear to be dependent ... -
Discovery of novel 3'-phosphoadenosine-5'-phosphosulfate (PAPS) reductase from methanarcheon Methanocaldococcus jannaschii.
(, 2013-09-24)This study explores the potential assimilatory sulfate reduction pathway in methanarcheon by investigating the gene product of the open reading frame Mj0066. We expressed and purified the gene product of Mj0066 of ... -
Electrochemistry and electron transfer induced substitution reactions of methylcyclopentadienylmolybdenum tricarbonyl complexes and electrospray ionization mass spectrometry and x-ray crystallographic characterization of related molybdenum complexes.
(Oxford, UK : Elsevier, 2007)The complexes Cp'Mo(CO)3X (X = Cl, Br, I; Cp' = C5H4CH3) and [Cp'Mo(CO)3(L)]+ (L = CH3CN, CH3COCH3) were synthesized and their electrochemistry and electron transfer induced substitution reactions were studied. Electrochemical ... -
Fueling advances in ultra performance liquid chromatography – and ion mobility – mass spectrometry as platforms for x-omic analyses.
(, 2012-08-08)Analysis of x-omics samples presents a significant challenge to analytical chemists. The complexity and diversity of x-omics samples make it difficult to determine or develop the right analytical approach. This dissertation ... -
Hierarchical stability based model selection for clustering algorithms.
(2009-09-09)We present an algorithm called HS-means, which is able to learn the number of clusters in a mixture model based on the hierarchical analysis of clustering stability. Our method extends the concept of clustering stability ... -
High-performance liquid chromatographic methods for quantitative assessment of degradation products and extractives in pretreated lignocellulose.
(Amsterdam : Elsevier B. V.Washington, D.C. : American Chemical Society., 2006)Long-term economic, national security, and environmental concerns have motivated research into renewable fuels from lignocellulosic biomass. Among energy alternatives, biomass-derived ethanol represents one of the more ... -
High-throughput analysis of emerging and historical pollutants in biological matrices.
(, 2013-05-15)The Deepwater Horizon Gulf Spill highlighted key deficiencies associated with our ability to analyze contaminants in biological tissue in a timely manner. These deficiencies in laboratory capacity and preparedness ... -
Identification and quantitation of potential fermentation inhibitors in biomass pretreatment hydrolysates using high performance liquid chromatography in combination with ultraviolet detection and tandem mass spectrometry.
(2010-02-02)Conversion of lignocellulosic biomass to ethanol involves pretreatment of biomass materials to increase the accessibility of carbohydrates in lignocellulose for enzymatic hydrolysis prior to ethanol fermentation. The ... -
Improved analytical methods for carbohydrate analysis in biofuel research.
(, 2013-09-16)Essential for continued growth of the biofuels industry is the need for continued development of rapid, robust, and accurate carbohydrate quantitation methods. As new feedstocks are identified and developed, understanding ... -
Inhibitors of human cathepsin L and cruzain as therapeutic agents.
(2009-04-01)Increased human cathepsin L activity is linked to invasive and metastatic cancers where it promotes degradation of the extracellular matrix. This major cysteine protease found in cell lysosomes and secreted from tissues, ... -
Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
(2008-06-16)Vascular disruption is an innovative method for treating cancer. By selectively altering the endothelial cells of tumor vasculature, the tumor can be destroyed by oxygen deprivation and starvation. The combretastatin ... -
Ion-exchange and electrochemical properties of tetra-t-alkylferrocenium monolayers on gold electrodes.
(2007-12-04)Five penta-substituted ferrocenes, each having one 11-SH-undecanoyl substituent, have been prepared from 1,1′,3,3′-tetra-t-alkylferrocenes and attached as electrochemically-assembled monolayers to gold electrodes (t-alkyl ... -
Kinetic characterization of thiosemicarbazones as cysteine protease inhibitors and their potential use as therapeutic agents against metastatic cancer and Chagas' disease.
(, 2013-05-15)Human cathepsins L and K are cysteine proteases that play important roles in physiological and pathological processes, such as cancer metastasis, bone resorption and neurodegenerative diseases. This research has focused ...