Browsing Theses/Dissertations - Biomedical Studies by Title
Now showing items 13-31 of 31
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Gamma Hydroxybutyrate (GHB): mechanisms of central nervous system toxicity.
(2006-07-31)Gamma Hydroxybutyrate (GHB) is an endogenous metabolite of gamma-aminobutyric acid (GABA) and a putative neurotransmitter found in mammalian brain. The illicit use of GHB is a growing health care concern in the U.S. Low ... -
Gene expression profiling to understand the alterations in the monocyte compartment of pediatric systemic lupus erythematosus.
(2008-06-11)Blood monocytes from SLE patients display DC function, as they are able to induce the proliferation of allogeneic T cells. Furthermore, sera from SLE patients induce healthy monocytes to differentiate into DCs. This ... -
Growth inhibition of human multiple myeloma cells by a conditional-replicative, oncolytic adenovirus armed with the CD154 (CD40-ligand) transgene.
(2007-03-08)Human multiple myeloma (MM) remains incurable despite successes in induction therapy. Based on our previous findings that treatment with the recombinant CD40L protein inhibited the growth of CD40+ human myeloma cell ... -
Humanized mice to test vaccination against influenza virus via dendritic cells.
(2008-06-11)Critical to the development of human vaccines is the availability of in vivo models of the human immune system that permit testing of vaccine efficacy. Here,we used NOD-SCID-β²m-/- immunodeficient mice which, when engrafted ... -
Identification of dysregulated miRNA targets in human prostate cancer.
(2010-02-02)MicroRNAs (miRNAs) are small, non-coding RNAs (18~24 nt) that regulate diverse cell functions in mammalian cells, including proliferation, differentiation, metabolism, stress resistance, and death. There is increasing ... -
Inhibition of β-lactamase I from Bacillus cereus by ssDNA.
(, 2011-09-14)Inhibitors of β-lactamases are important to the treatment of infectious diseases when used in conjunction with a β-lactam antibiotic. Current inhibitors of β-lactamase such as clavulanic acid, sulbactam, and tazobactam ... -
Investigating the role of novel gene -C20orf197.
(2016-04-05)The C20orf197 gene which is on chromosome 20 open reading frame 197, was sequenced at least 15 years ago, but even today, it still remains uncharacterised for the public. Meanwhile, over the last few decades it has become ... -
Leveraging available data for contaminants of emerging concern to develop an understanding of environmental hazard.
(, 2011-09-14)Contaminants of emerging concern (CEC) are classes of compounds with relatively limited information available on environmental exposure, fate, and effects. The purpose of this research was to develop and test approaches ... -
Molecular mechanisms in low-serotonin induced mood and anxiety disorders.
(2010-10-08)The amygdala has been shown to be involved in both epilepsy and emotional disturbances such as in mood and anxiety disorders. It is suggested that anxiety and mood disorders may be the result of sub-seizure hyperexcitability ... -
A possible mechanistic role for microorganisms in the genesis of colorectal cancer.
(, 2013-09-24)Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. An estimated over 140,000 people will be diagnosed with CRC and over 50,000 people will die in 2013. CRC tumors develop ... -
The recombinant expression of two pollen allergens using plant-viral and yeast expression systems.
(2006-05-09)Allergic disease causes much distress within industrialized areas of the world, affecting approximately a quarter of the population in such areas. Current immunotherapy involves the administration of increasing concentrations ... -
Reprogramming T cell specific immune responses to Cyclin B1 in breast cancer patients using a TLR 8/7 agonist.
(, 2012-08-08)Cyclin B1 is a cell cycle regulatory protein aberrantly overexpressed in a number of cancers, including breast cancer. While the current standards of care for breast cancer are sometimes curative, many patients suffer ... -
Reprogramming the immune environment in breast cancer via dendritic cells.
(, 2013-09-24)Breast cancer is the most common cancer among American women. The current therapies are not curative for some forms of breast cancer, especially breast cancers that do not express the growth factor and hormone receptors ... -
Respiratory Syncytial Virus triggers immune tolerance through induction of tolerogenic dendritic cells and expansion of regulatory T cells.
(2010-06-23)Dendritic cells have the ability to control the balance between immunity and tolerance. Upon viral exposure, Dendritic Cells (DCs) steadily detect pathogens and exert their antigen presentation function to induce adaptive ... -
RNAi screen for novel components in Caenorhabditis elegans ovulation and fertility.
(2010-02-02)The intercellular and intracellular signaling pathways elucidated through research on the nematode C. elegans provide valuable information on the communication systems throughout all organisms. Through the use of RNA ... -
Structural analysis of biomolecules using ion mobility and mass spectrometry : exploration of ion rearrangements and conformations.
(2016-03-21)Early diagnosis of diseases is dependent on the development of reliable physiological and biochemical tests. The most precise medical tests employ analytical methods to identify specific molecules (“biomarkers”) or molecular ... -
Structure, dynamics, and interactions of Angiotensin family of peptides with functional implications.
(, 2011-12-19)We present a study of structural analysis and reorientational dynamics of the angiotensin family of peptides. AngI is a decapeptide that acts as a precursor to the octapeptide, AngII in the Renin Angiotensin Aldosterone ... -
Targeting the immune microenvironment to treat breast cancer.
(, 2014-06-11)In tumor microenvironment, the crosstalk between infiltrating inflammatory cells and tumor cells creates a cytokine milieu which can promote both oncogenesis and tumor rejection. We have found an IL-13 dominant cytokine ... -
To giveth and taketh away : determination of taurine's protective role during ethanol withdrawal through supplementation and depletion paradigms.
(2009-04-01)The β-amino acid taurine, whose primary physiological roles involve osmoregulation and calcium modulation, exists as one of the most concentrated amino acids in the mammalian brain. As a neuroinhibitor and neuromodulator, ...