Effects of glucosamine and chondroitan supplementation in women with knee osteoarthritis participating in the Curves fitness and weight loss program: a randomized, placebo controlled, double blind clinical trial.
Access RightsWorldwide access
MetadataShow full item record
The purpose of this study was to determine whether participation in the Curves fitness and weight loss program and/or ingesting a commercially available glucosamine and chondroitan joint support dietary supplement improved functional status and/or health outcomes in women with knee osteoarthritis (OA). Thirty sedentary women with OA participated in a 14-week exercise and diet program and ingested either a glucosamine and chondroitan supplement or placebo. Participants were assigned to follow an isoenergenic high protein/carbohydrate restricted diet (HPD) or high carbohydrate/low protein diet (HCHO). Subjects participated in a supervised 30-minute resistance training circuit program that was interspersed with calisthenic exercises and performed 3-d per week. At 0, 2, 10, and 14 weeks, subjects completed a battery of assessments. Data were analyzed by repeated measures analysis and are presented as means ± SD from baseline. Results indicated that women with knee OA experienced significant training adaptations including decreased body mass (3±4%), decreased fat mass (6%±8), decreased body fat (4%±3), increased 1 repetition maximal muscular strength (11%±12), increased muscular endurance (13%±12), increased isokinetic strength (ranging from 10-25%±4), decreased knee pain (112%±317), stiffness (70%±234), limitations in physical function (96%±1,356), improved quality of life variables of physical functioning (37%±52), energy/fatigue (55%±69), social functioning (40%±76), and mental health (22%±84). Perceptions of appetite (13%±36), hunger (17%±34), energy (24%±35), and quality of diet (19%±38) were also improved. Glucosamine chondroitan supplementation tended to decrease perceptions of pain, with no statistically significant improvement in strength, or functional status. However, a strong effect size (d=1.1) was observed in VAS knee pain and moderate effect sizes were observed in WOMACTM pain (d=0.4), left knee flexion (d=0.53), 1 repetition max (d=0.53), total work (d=0.72), and maximal systolic blood pressure (d=0.69). These findings suggest that glucosamine and chondroitan supplementation during a weight loss and fitness program may have therapeutic benefits for women with OA.