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dc.contributor.advisorStamey, James D.
dc.contributor.authorHand, Austin L.
dc.contributor.otherBaylor University. Dept. of Statistical Sciences.en
dc.date.accessioned2011-05-12T15:32:35Z
dc.date.available2011-05-12T15:32:35Z
dc.date.copyright2011-05
dc.date.issued2010
dc.identifier.citationHand, Austin L., Stamey, James D., and Young, Dean M. "Bayesian sample-size determination for two independent Poisson rates." Computer Methods and Programs in Biomedicine (2010): doi:10.1016/j.cmpb.2010.10.010.en
dc.identifier.urihttp://hdl.handle.net/2104/8144
dc.description.abstractBecause of the high cost and time constraints for clinical trials, researchers often need to determine the smallest sample size that provides accurate inferences for a parameter of interest or need to adaptive design elements during the course of the trial based on information that is initially unknown. Although most experimenters have employed frequentist methods, the Bayesian paradigm offers a wide variety of methodologies and are becoming increasingly more popular in clinical trials because of their flexibility and their ease of interpretation. Recently, Bayesian approaches have been used to determine the sample size of a single Poisson rate parameter in a clinical trial setting. We extend these results to the comparison of two Poisson rates and develop methods for sample-size determination for hypothesis testing in a Bayesian context. Also, we propose a Bayesian predictive adaptive two-stage design for Poisson data that allows for sample-size adjustments by basing the second-stage sample size on the first-stage results. Lastly, we present a new Bayesian meta-analytic non-inferiority method for binomial data that allows researchers a more direct interpretation of their results. Our method uses MCMC methods to approximate the posterior distribution of the new treatment compared to a placebo rather than indirectly inferring a conclusion from the comparison of the new treatment to an active control.en
dc.description.statementofresponsibilityby Austin L. Hand.en
dc.format.extent394094 bytes
dc.format.extent1147382 bytes
dc.format.extent65265 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.publisherElsevier.en
dc.rightsBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.en
dc.subjectBayesian.en
dc.subjectSample-size determination.en
dc.subjectMeta-analysis.en
dc.subjectNon-inferiority.en
dc.subjectPoisson.en
dc.subjectBinomial.en
dc.subjectClinical trials.en
dc.titleBayesian sample-size determination and adaptive design for clinical trials with Poisson outcomes.en
dc.typeThesisen
dc.description.degreePh.D.en
dc.rights.accessrightsWorldwide accessen
dc.contributor.departmentStatistical Sciences.en


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