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dc.contributor.advisorBruce, Erica Dawn.
dc.contributor.authorRawat, Swati, 1984-
dc.date.accessioned2011-12-19T20:01:23Z
dc.date.available2011-12-19T20:01:23Z
dc.date.copyright2011-12
dc.date.issued2011-12-19
dc.identifier.urihttp://hdl.handle.net/2104/8277
dc.description.abstractPolybrominated diphenyl ethers (PBDEs) are becoming increasingly known as effective flame retardants and have vast industrial application in products like plastics, building materials, and textiles. They are found to be structurally similar to thyroid hormones that are responsible for regulating metabolism in the body. Structural similarity with the hormones poses a threat to human health because once in the system, the PBDEs may change thyroid hormone transport and metabolism. This study is aimed at designing QSAR models for predicting toxic endpoints for PBDEs in mammalian cells. QSAR modeling uses the known chemicals’ activity, which serve as surrogates to study unknown chemicals belonging to the same family. This research is a threefold process including running in-vitro bioassays to collect data on the toxic endpoints, modeling the evaluated endpoints using QSARs and validating the models using compounds of interest from the same family (PBDEs).en_US
dc.language.isoen_USen_US
dc.publisheren
dc.rightsBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.en_US
dc.subjectPolybrominated diphenyl ethers (PBDE)en_US
dc.subjectQuantitative Structure Activity Relationships (QSAR)en_US
dc.subjectToxicity.en_US
dc.subjectMammals.en_US
dc.subjectCell culture systems.en_US
dc.titleDesigning quantitative structure activity relationships (QSAR) to predict specific toxic endpoints for polybrominated diphenyl ethers (PBDE) in mammalian cell culture systems.en_US
dc.typeThesisen_US
dc.description.degreeM.S.en_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 5/21/14.
dc.contributor.departmentEnvironmental Science.en_US
dc.contributor.schoolsBaylor University. Dept. of Environmental Science.en_US


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