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dc.contributor.advisorFarmer, Patrick
dc.contributor.authorSartor, Zachary
dc.contributor.otherBaylor Universityen_US
dc.contributor.otherTexas A&M Health Sciences Center College of Medicine- Newell Research Laboratoryen_US
dc.date.accessioned2012-05-03T16:24:56Z
dc.date.available2012-05-03T16:24:56Z
dc.date.copyright2012
dc.date.issued2012-05-03
dc.identifier.urihttp://hdl.handle.net/2104/8356
dc.description.abstractAlthough melanoma accounts for a very small percentage of all skin cancer cases, it is the most responsible for skin cancer related deaths. Therapeutic agents that induce apoptosis in the cancer cells have been heavily researched. Some recent research has focused on enhancing the effects of apoptotic agents by blocking autophagy, a cancer survival mechanism where the cells digest themselves. Research has shown that inhibiting this pathway with certain drugs can lead to cell death at a greater rate than by using apoptosis inducing agents alone. However, the universal application of blocking autophagy is debated by most researchers. The main question this study seeks to answer is whether the effects of an autophagy blocking agent used alongside an apoptosis inducing drug will increase cell death at levels higher than using the drug alone. The apoptotic drug used is thiomaltol (Htma). The autophagy blocking agent used is hydroxychloroquine (HCQ). The two compounds are tested against B16F1 melanoma cells from mice. Overall, data indicates that although the activity of Htma in these cells is not as high compared to other cell lines, there is an increase in cell death when both Htma and HCQ are administered. This increase in activity is higher when the compounds are administered over an extended period of time.en_US
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.subjectmelanomaen_US
dc.subjectautophagyen_US
dc.subjectapoptosisen_US
dc.titleSynergistic Effects of Hydroxychloroquine on the Activity of Thiomaltol against Melanoma Cancer Cellsen_US
dc.typeThesisen_US
dc.rights.accessrightsWorldwide accessen_US
dc.contributor.departmentChemistry and Biochemistryen_US
dc.contributor.schoolshonors collegeen_US


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