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dc.contributor.advisorPennington, David
dc.contributor.authorNaumann, Matthew
dc.contributor.otherBaylor University.en_US
dc.date.accessioned2012-05-04T21:36:56Z
dc.date.available2012-05-04T21:36:56Z
dc.date.copyright2012
dc.date.issued2012-05-04
dc.identifier.urihttp://hdl.handle.net/2104/8374
dc.description.abstractThe so-called glucose tolerance factor (GTF) is believed to be a biological complex of chromium that works alongside insulin to enhance the body’s ability to metabolize sugar. Chromium and cobalt complexes with glutathione were synthesized as potential analogues to the GTF. These were then analyzed via mass spectrometry and UV-visible absorption for potential clues to the composition and connectivity of the complexes. Upon analysis, the cobalt complex with glutathione appeared to have an uncoordinated sulfhydryl group, consistent with the hypothesis that the GTF interacts with the insulin receptor via a sulfhydryl-disulfide exchange. Such a complex could theoretically be tested for GTF activity.en_US
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.subjectCoordination chemistry.en_US
dc.subjectGlucose tolerance factor.en_US
dc.subjectCobalt(III).en_US
dc.subjectChromium(III).en_US
dc.subjectGlutathione.en_US
dc.titleCobalt(III), Chromium(III), Glutathione, and Their Relevance to the Glucose Tolerance Factoren_US
dc.typeThesisen_US
dc.rights.accessrightsWorldwide accessen_US
dc.contributor.departmentChemistry and Biochemistryen_US
dc.contributor.schoolshonors collegeen_US


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