Browsing by Title
Now showing items 3943-3962 of 4624
-
Synthesis of a Novel Benzosuberene Analogue as an Anti-Cancer Agent
Cancer is a highly prevalent disease characterized by abnormal growth and uncontrolled division of cells. While many current treatments modalities are powerful in their ability to damage and potentially destroy tumors, ... -
Synthesis of amyloid-selective lysine acetylating agents, synthetic studies toward the total synthesis of (±)-caseabalansin A, and progress toward the total synthesis of (±)-isopalhinine A.
(2021-04-07)Repulsive electrostatic forces between prion-like proteins limit the aggregation between them. In medicinal chemistry, a protein’s net electrostatic charge (Z) is an uncommon target and compounds that increase a prion’s Z ... -
Synthesis of Chiral Tetramic Acids: Preparation of (S)-5-Benzylpyrrolidine-2,4-dione from L-Phenylalanine Methyl Ester Hydrochlorides and Synthetic Efforts Towards Dracocephalone A
(2020-09-02)The pyrrolidine-2,4-dione moiety, colloquially known as tetramic acid, is a highly versatile molecular scaffold underpinning many biologically active natural products. That is to say, natural products containing these ... -
Synthesis of modulators of TLR2, TLR4, and TLR7 functionalized for conjugation to biomolecules.
(2016-11-09)A wide range of pathogen-associated molecules including acylated lipopeptides, lipopolysaccharides (LPS), and single-stranded viral RNAs initiate an innate immune response via binding to members of a protein family called ... -
Synthesis of new chiral pyrylium salts, the corresponding phosphinine and pyridine derivatives and the kinetic studies of the epimerization of pyrylium salts.
(, 2013-09-16)Despite the versatility of pyrylium salts as precursors to many heteroaromatic systems, chiral pyrylium salts are almost unknown in the literature. One reason for this scarcity is that pyrylium salts are often involved ... -
The Synthesis of New Pyrylium and Pyridinium Salts
(2013-05-23)The synthesis, properties, and applications of symmetrical and unsymmetrical pyrylium and pyridinium salts is investigated. Our group has found particular interest in chiral pyrylium salts due to the fact that they are ... -
Synthesis of Nitrile Tak-242 Derivatives and Gemfibrozil Analogs
(2020-05-20)TAK-242 (resatorvid) is a selective antagonist of Toll-like receptor 4 (TLR4) signaling, previously shown to improve transplantation outcomes in a murine model. To further expand the structure-activity relationship of ... -
Synthesis of protected amino thymidines and new thiol derivatives of the vascular targeting agent combretastatin A-4.
(2007-03-08)Protected amino thymidines were synthesized as part of a project aimed at developing reagents for the site-specific, sequence selective DNA cleavage. Modified DNA oligonucleotides have the capacity to behave like artificial ... -
Synthesis of Small Molecule Vascular Disrupting Agents and Cathepsin B Cleavable Linker to Develop Antibody-Drug Conjugates for Cancer Treatment
(2016-08-10)Vascular disrupting agents (VDAs), a subclass of vascular targeting agents (VTAs), represent an emerging therapeutic strategy for targeting tumor vasculature to impart irreversible vessel damage leading to tumor necrosis. ... -
Synthesis of spongiolactone-based alkynyl proteomic probes, (+)-hypercalin C, and pharmacophore-directed retrosynthesis of ophiobolins.
(2020-04-15)The spongiolactones are β-lactone containing marine natural products with fused tricyclic β-lactone-containing ring system. We synthesized bis-epi-spongiolactone and its corresponding alkynyl probe. Our collaborators (Prof. ... -
Synthesis of Sulfur and Amino 8-Substituted Adenine Derivatives as TLR7 Agonists
Toll-like receptors (TLRs) are a class of pattern recognition receptor (PRR) proteins, which play a vital role in the innate immune response. Upon recognition of microbial pathogens, TLRs initiate pathways which lead to ... -
Synthesis of Vascular Disrupting Agent Payloads, Protease Specific Linkers, and their Corresponding Constructs
(2020-05-20)The discovery and development of small-molecule anticancer agents that are both highly efficacious and selectively targeted remains a formidable goal and challenge. Conventional chemotherapy regimens often employ the use ... -
Synthesis, characterization, and applications of redox-mediated ion exchangers.
(2007-12-04)The technology for conversion of lignocellulosic biomass resources to fuels and chemicals has been under development for decades. There are many process configurations for conversion of biomass to ethanol, one of the ... -
Synthesis, characterization, and biological evaluation of bioreductively activatable prodrug conjugates (BAPCs) of phenstatin, KGP18, OXi6196, combretastatin A-1, and combretastatin A-4.
(2017-01-20)Selective targeting of tumors with anticancer agents represents a universally important strategy to improve efficacy and reduce patient side effects. Targeting tumor-associated hypoxia (low oxygen tension) represents one ... -
Synthetic coenzymes for in vitro selection of DNA enzymes.
(2007-01-22)Over the past 10 years a number of catalytically active single-stranded DNA molecules (deoxyribozymes) have been isolated from combinatorial libraries (pools) of randomized oligonucleotides. These enzyme-like DNAs customarily ... -
Synthetic studies toward the total syntheses of scholarisine A and phomoidride D.
(2015-01-06)Isolated in 2008 from a leaf extract of an Alstonia scholaris variant, scholarisine A contains a unique pentacyclic architecture that makes it a challenging target for total synthesis. Our approach toward the molecule’s ... -
Synthetic studies towards penicisulfuranol B; C-H activation borylation of staurosporine; design, synthesis, and evaluation of rapamycin and everolimus analogs; design, synthesis, and evaluation of gemfibrozil analogs.
(2021-07-26)Penicisulfuranol B and several penicisulfuranol congeners were first isolated in 2017 by Li and coworkers from the Penicillium janthinellum strain HDN13-309 found on the root of the crabapple mangrove Sonneratia caseolaris. ... -
A Systematic Review of Opioids in the United States
(2021-05-18)The opioid epidemic is a prevalent concern in American society as overdose deaths continue to increase. Heroin, fentanyl, carfentanil, hydrocodone, and krokadil are five of the most dangerous opioids and they are responsible ... -
A Systematic Review of Recent Literature on religiousity, Stress, Depression, and Prescription Stimulant Misuse
This paper contains a systematic review of articles about the relationships between religious identity, stress, depression, and prescription stimulant misuse that were published between 2010 and 2015. Summaries of ...