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dc.contributor.advisorHotez, Peter
dc.contributor.authorLe, David Thien
dc.date.accessioned2017-05-25T00:01:12Z
dc.date.available2017-05-25T00:01:12Z
dc.date.copyright2017
dc.date.issued2017-05-24
dc.identifier.urihttp://hdl.handle.net/2104/10012
dc.description.abstractA significant public health concern is the control of parasitic nematodes in order to minimize the burden of lymphatic filariasis in endemic regions. The development of a vaccine is a potentially cost-effective approach towards control and elimination of this parasitic disease. Based on a genome-wide analysis of the developmental stages of the filarial parasite Brugia pahangi, molecular targets for interrupting the development of the filarial parasites were identified. Using genetic engineering technology and protein expression systems, five vaccine antigens were cloned and expressed as recombinant proteins in yeast and bacterial expression platforms. With this preliminary evidence, we believe these proteins are expressible for pilot-scale biomanufacturing for preclinical trials, but further evaluation of the vaccine antigens will prove useful for accelerating and prioritizing them down through the development pipeline. Initial bioinformatics analysis has elucidated possible peptide sequences that could act as epitopes in the vaccination process. With the following results, efforts towards creating a transmission blocking vaccine TBV for LF can be feasibly attainable, and the proposal for building a recombinant subunit vaccine or a multiple antigen peptide system is suggested.en_US
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.subjectNeglected Tropical Diseasesen_US
dc.subjectVaccinologyen_US
dc.subjectMolecular Biologyen_US
dc.subjectBioinformaticsen_US
dc.titleEvaluation of Vaccine Antigens Against Lymphatic Filariasisen_US
dc.typeThesisen_US
dc.rights.accessrightsWorldwide accessen_US
dc.contributor.departmentBiochemistry.en_US
dc.contributor.schoolshonors collegeen_US


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