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dc.contributor.advisorLee, Myeongwoo
dc.contributor.authorKumar, Amy
dc.contributor.authorGakhar, Shiv
dc.contributor.authorHarris, Julian
dc.contributor.authorStory, Shelby
dc.contributor.authorVo, Henry
dc.contributor.authorVo, Bill
dc.contributor.otherBaylor University.en_US
dc.date.accessioned2020-04-21T19:15:35Z
dc.date.available2020-04-21T19:15:35Z
dc.date.copyright2019
dc.date.issued2020-04-21
dc.identifier.urihttps://hdl.handle.net/2104/10819
dc.description.abstractC. elegans, a nematode, is a model organism to study animal behavior and development. The genome of the C. elegans shows that there is a similarity between the genes of the nematode and that of humans. C. elegans are widely used because of its rapid life cycle and its small size which makes it easy for laboratory cultivation. The str-2 gene in C. elegans is predicted to be responsible for receptor activity linked to olfactory responses. Through the binding of odorants on specific olfactory receptors, str-2 allows them to detect pheromones, environmental threats, and nutrition—essentially playing a vital role in their behavioral functioning. The egg-laying behavior of C. elegans is regulated by its surroundings and can be activated or inactivated through various environmental cues. However, without a properly functioning olfactory system, we hypothesize that C. elegans will be unable to initiate standard egg-laying activity through its inability to pick up on these environmental cues—even if they are in the presence of serotonin. In this study, we created a mutagenized str-2 C. elegans that was induced by ethyl methanesulfonate (EMS) which would also be resistant to the egg-laying ability response to serotonin. The C. elegans were treated and screened to ensure that they represented their ability to lay the least eggs in response to serotonin. Egg laying assays were repeated until the offspring was uniform. We found that in the life cycle of the the str-2 mutants were found have a decreased life cycle compared to the non-mutants. These mutants had crippled olfactory responses to environmental transmitters, and lacked sensory abilities that hindered life. In addition, we found that the number of offspring produced by the mutants were significantly less than those of the non-mutants.en_US
dc.language.isoEnglishen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.subjectStr-2 gene. C elegans.en_US
dc.titleGenetic suppressors of str-2 serotonin response defects in Caenorhabditis elegansen_US
dc.typePresentationen_US
dc.rights.accessrightsWorldwide accessen_US
dc.contributor.departmentBaylor University. Dept. of Biologyen_US
dc.contributor.schoolsBaylor University. Dept. of Biologyen_US


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