The Importance of Cathepsin B Research and Clinical Applications

Date

2020

Authors

Kosa, David

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Worldwide access

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Abstract

Cathepsin B is a cysteine protease of the papain family. It plays an important role in intracellular proteolysis, but it displays exopeptidase activity due to a unique structural element called the occluding loop. There is also a large amount of evidence that cathepsin B is involved in the development and progression of cancer, Alzheimer’s disease, and pathological conditions. Throughout this thesis cathepsin B is analyzed for its role in pathology, enzyme mechanisms, and protease activity.

Description

Keywords

Cathepsin B., Cysteine protease., Alzheimer's disease., Cancer., Intracellular proteolysis.

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