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dc.contributor.advisorSimmons, Dwayne
dc.contributor.authorCharles, Jack
dc.contributor.otherBaylor Universityen_US
dc.date.accessioned2022-05-18T20:08:45Z
dc.date.available2022-05-18T20:08:45Z
dc.date.copyright2022
dc.date.issued2022-05-18
dc.identifier.urihttps://hdl.handle.net/2104/11813
dc.description.abstractHearing loss is a complicated disability affecting a substantial portion of the public. Hearing loss can occur due to a variety of reasons, but the processes involved in such a phenomenon are considered to be similar across all types of hearing loss. Here, an oncomodulin knock-out (KO) mouse strain is used to resemble an age-related hearing loss model. Oncomodulin (OCM) is a calcium binding protein (CaBP) in mammalian outer hair cells (OHC) responsible for calcium regulation. OCM is the dominant CaBP and is the only known CaBP whose KO is known to cause progressive hearing loss. Thus, this study sought to examine changes in the OHC that occur in response to its deletion. Of interest were OHC survivability, electromotive function, efferent cluster connections, and secondary CaBP expression, all of which are proposed mechanisms involved in hearing loss. This study hypothesized that the calcium dysfunction resulting from Ocm KO leads to changes in these four areas, which contributes to eventual hearing loss. Upon analysis, it was found that OHC survivability and efferent cluster expression are mediated by calcium regulation, while secondary CaBP activity and electromotive function appear unaffected. These findings suggest that OHC presence and efferent connections are primarily involved in processes resulting in age-related hearing loss, and that these mechanisms are regulated by OCM function.en_US
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.subjectBiology.en_US
dc.subjectMolecular biology.en_US
dc.subjectCell biology.en_US
dc.subjectOncomodulin.en_US
dc.subjectHearing loss.en_US
dc.subjectCalcium.en_US
dc.subjectOuter hair cell.en_US
dc.subjectCalcium binding protein.en_US
dc.subjectMicrodissection.en_US
dc.subjectImmunofluorescence.en_US
dc.subjectKnockout.en_US
dc.subjectMurine model.en_US
dc.subjectElectromotility.en_US
dc.subjectEfferent nerves.en_US
dc.subjectDistortion product otoacoustic emissions.en_US
dc.titleDysfunction of Calcium Regulation Mediates Processes Involved in Age-Related Hearing Lossen_US
dc.typeThesisen_US
dc.rights.accessrightsWorldwide accessen_US
dc.contributor.departmentNeuroscience.en_US
dc.contributor.schoolsHonors College - Honors Programen_US


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