Unique fragmentation of pentafluorobenzylic alcohols and the use of modified injection port liners in the gas chromatographic-based screening for catalytic activity.
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Fisher, Henry C.
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An unprecedented reaction, the base-catalyzed fragmentation of pentafluorobenzylic alcohols, was investigated. Studies on a variety of C6F5-derived alcohols show that a dual reaction pathway occurs in mixed solvent systems such as DMSO and methanol. 19F NMR and GC-MS analyses have been used to examine the mechanism of the fragmenation. Other reaction variables, which involved changing the base and/or solvent conditions, have been studied to determine their effect on fragmentation. The relative rates of reactivity of a variety of pentafluorobenzylic alcohols were determined. A new technique to screen metal catalysts rapidly via GC-MS using modified injection port liners has been developed. A variety of interesting reactions of organic molecules catalyzed by metal salts in the gas phase have been discovered. This technique has also been applied to the fragmentation reactions above.