Effects of eight weeks of 6-OXO supplementation on serum hormone profiles and on serum and urinary clinical safety markers in resistance-trained males.
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2006-05-28Author
Rohle, Daniel A.
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The purpose of this study was to determine the effects of 6-OXO, an aromatase
inhibitor, in a dose dependent manner on serum hormone levels and clinical safety
markers in resistance trained males. Sixteen healthy trained subjects, who participated in
a resistance training protocol, had blood samples taken at weeks 0, 1, 3, 8, and 11. These
samples were analyzed for total testosterone, free testosterone, DHT, estradiol, estriol,
estrone, SHBG, LH, FSH, GH, and cortisol. There were no significant differences
between groups (p>0.01). However, total testosterone concentration, free testosterone
concentration, and DHT concentration increased over the course of the study (p=0.009).
Measures of body composition did not change with supplementation (p>0.05). Safety
markers were seen to not be adversely affected with ingestion of 6-OXO (p>0.01).
6-OXO supplementation appears to be safe and increases total testosterone, free
testosterone, and DHT concentrations independent of the two different doses.