Effects of eight weeks of 6-OXO supplementation on serum hormone profiles and on serum and urinary clinical safety markers in resistance-trained males.

Abstract

The purpose of this study was to determine the effects of 6-OXO, an aromatase inhibitor, in a dose dependent manner on serum hormone levels and clinical safety markers in resistance trained males. Sixteen healthy trained subjects, who participated in a resistance training protocol, had blood samples taken at weeks 0, 1, 3, 8, and 11. These samples were analyzed for total testosterone, free testosterone, DHT, estradiol, estriol, estrone, SHBG, LH, FSH, GH, and cortisol. There were no significant differences between groups (p>0.01). However, total testosterone concentration, free testosterone concentration, and DHT concentration increased over the course of the study (p=0.009). Measures of body composition did not change with supplementation (p>0.05). Safety markers were seen to not be adversely affected with ingestion of 6-OXO (p>0.01). 6-OXO supplementation appears to be safe and increases total testosterone, free testosterone, and DHT concentrations independent of the two different doses.