Search
Now showing items 1-10 of 69
Design, synthesis, and biological evaluation of dihydronaphthalene and chalcone-based anticancer agents inspired by the natural product combretastatin A-4.
(2019-04-17)
Hallmarks of tumor progression include, abnormal tumor-associated vasculature, regions of hypoxia, and overexpressed proteins. These abnormalities provide opportunities for therapeutic intervention though various targeting ...
Improved analytical methods for carbohydrate analysis in biofuel research.
(, 2013-09-16)
Essential for continued growth of the biofuels industry is the need for continued development of rapid, robust, and accurate carbohydrate quantitation methods. As new feedstocks are identified and developed, understanding ...
Unimolecular decomposition kinetics at resolved internal energies.
(2016-12-01)
The kinetic behavior of microcanonical unimolecular decomposition reactions involving clusters formed by the electrostatic interaction between transition metal cations and simple organic molecules has been measured at ...
Synthesis and evaluation of 8-substituted adenine derivatives as toll-like receptor 7 agonists.
(2015-04-08)
Toll-like receptors (TLRs) are immune cell receptors that have the ability to recognize microbial pathogens and trigger innate immune responses. Research into TLR7 agonists is of specific interest because they can induce ...
Cavity ring down and thermal lens techniques applied to vibrational spectroscopy of gases and liquids.
(2017-06-15)
Infrared (IR) and near-infrared (NIR) region gas temperature sensors have been used in the past because of its non-intrusive character and fast time response. In this dissertation cavity ring down (CRD) absorption of oxygen ...
Design and implementation of a custom imaging mass spectrometer.
(2019-07-26)
Mass spectrometry (MS) has been demonstrated as one of the most robust and capable analytical tools for chemical analysis. As such, MS has found application across practically every field of science today. One notable area ...
Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents.
(, 2012-08-08)
Targeting the vascular network that supplies a tumor with oxygen and nutrients is a viable methodology for the treatment of cancer. With the discovery of the combretastatin extended family of compounds in the late 1970's ...
High-throughput analysis of emerging and historical pollutants in biological matrices.
(, 2013-05-15)
The Deepwater Horizon Gulf Spill highlighted key deficiencies associated with our ability to analyze contaminants in biological tissue in a timely manner. These deficiencies in laboratory capacity and preparedness ...
Total syntheses of (+)- and (–)- tetrapetalones A and C.
(2018-02-27)
The total syntheses of polyketide natural products (–)-/(+)-tetrapetalone A and (–)-/(+)-tetrapetalone C are described. In 2003, during their pursuit for novel lipoxygenase inhibitors, Hirota and coworkers reported the ...
Kinetics and mechanistic detail of Ni⁺ assisted organic decomposition reaction at low internal energies.
(, 2011-12-19)
The unimolecular decomposition kinetics of jet-cooled cluster ions have been monitored over ranges of internal energies. The clusters are formed by the combination of Ni cation with and organic ketone, aldehyde or ether ...