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Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
The rate at which pathogenic bacteria are gaining antibiotic resistance has become increasingly alarming. Major contributors of this antibiotic resistance in microbes are a class of enzymes known as β-lactamases. These ...
Purification, characterization, and kinetic analysis of various metallo-β-lactamases and discovery of novel inhibitors of these enzymes.
Pathogenic bacteria are rapidly becoming antibiotic resistant, at a rate much faster than the production and FDA approval of new antibiotics that can combat these extreme resistant infections. One way to overcome antibiotic ...