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Discovery of DNA-enzymes dependent on small-molecule cofactors; design, synthesis and evaluation of TLR-7 agonists and their immunoprotein conjugates.
(2010-10-08)
Several catalytic families of DNA enzymes (deoxyribozymes) have previously been isolated through the use of an in vitro selection technique in our laboratory. The activities of these deoxyribozymes appear to be dependent ...