Theses/Dissertations - Chemistry & Biochemistry
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Investigating the chemistry of the 9-borataphenanthrene anion.
(2021-07-12)Boron-containing analogues of unsaturated hydrocarbons exhibit a diverse array of reactivity modes that can be exploited for the synthesis of other more complex boron-containing compounds. Examples of such analogues include ... -
Targeted and non-targeted analysis of pesticides, algal toxins, and human pharmaceuticals in aquatic systems.
(2021-06-14)It is well known that complex, chemical mixtures exist in the environment, particularly aquatic systems. Originally designed to treat illnesses, support crop production, and clean, among other uses, chemicals can enter ... -
Synthesis of spongiolactone-based alkynyl proteomic probes, (+)-hypercalin C, and pharmacophore-directed retrosynthesis of ophiobolins.
(2020-04-15)The spongiolactones are β-lactone containing marine natural products with fused tricyclic β-lactone-containing ring system. We synthesized bis-epi-spongiolactone and its corresponding alkynyl probe. Our collaborators (Prof. ... -
Expanding the reactive sulfur species metabolome : characterization of small oxoacids of sulfur and hydrogen sulfide within in vitro and in vivo models and use of the ionophore thiomaltol to target melanoma in a copper-dependent mechanism.
(2022-02-03)Hydrogen sulfide (H2S) is an endogenously produced signaling molecule with vast regulatory function in cardiovascular physiology controlling vasodilation, amelioration of hypoxia, and blood pressure. While the enzyme systems ... -
Understanding the singlet oxygen reactivity of salarin C through synthesis of a simplified macrocyclic analogue; multicomponent, enantioselective organocatalytic synthesis of tetrahydropyridazinones.
(2021-10-27)Natural products are a valuable source of inspiration for the discovery of new anticancer therapeutic agents. Sponges, especially, produce a wide variety of cytotoxic chemical defense agents. The macrolide salarin C is one ... -
Unveiling the orientation, conformations, and contacts of replicative hexameric DNA helicases that govern DNA replication dynamics.
(2021-11-10)Replication of chromosomal DNA is an intricate process carefully orchestrated in all living organisms by a multiprotein molecular machine known as the replisome. The replicative DNA helicase motor protein is at the forefront ... -
Design and activation of small organic molecules for localized immunosuppression.
(2021-08-27)Since the implementation of the Edmonton Protocol in the early 2000s, many efforts have been made to further improve the long-term viability of transplanted islets in recipients with type 1 diabetes mellitus. These efforts ... -
Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein.
(2021-08-05)How various macromolecules come together to form specific biological complexes and how the assembly/disassembly of such complexes are regulated are key to understanding any biological process. Characterization of such ... -
The development of prodrug strategies for the targeted delivery of dihydronaphthalene and benzosuberene inhibitors of tubulin polymerization.
(2021-08-02)The abnormalities present in tumor vasculature provide a promising opportunity for targeted therapeutic approaches. Vascular disrupting agents (VDAs) damage the existing tumor vasculature limiting the delivery of oxygen ... -
Computational study of glycopeptide antibiotics interactions with Staphylococcus aureus peptidoglycan.
(2021-08-04)Staphylococcus aureus is generally known for its ability to acquire resistance to any antibiotic. Methicillin-resistant S. aureus is one of the leading etiological agents responsible for the hospital- and community-acquired ... -
Development of chemical classification and annotation tools for metabolomics and lipidomics MS analyses.
(2021-08-02)Within the context of mass spectrometry (MS), chemical annotation is the process of assigning elements of chemical identity such as structure, stereochemistry, elemental composition (EC), and class to previously unknown ... -
Design, synthesis, and biological evaluation of benzosuberene and chalcone-based tubulin binding agents inspired by the natural product combretastatin A-4 and prodrugs targeting tumor-associated hypoxia.
(2021-08-03)Cancer therapeutic strategies have moved, increasingly, toward methods that are designed to exploit inherent characteristics of tumor cells and the tumor microenvironment. One strategy is to take advantage of the primitive ... -
Synthetic studies towards penicisulfuranol B; C-H activation borylation of staurosporine; design, synthesis, and evaluation of rapamycin and everolimus analogs; design, synthesis, and evaluation of gemfibrozil analogs.
(2021-07-26)Penicisulfuranol B and several penicisulfuranol congeners were first isolated in 2017 by Li and coworkers from the Penicillium janthinellum strain HDN13-309 found on the root of the crabapple mangrove Sonneratia caseolaris. ... -
Prion-like aggregation of Cu, Zn superoxide dismutase in amyotrophic lateral sclerosis.
(2021-08-10)Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) are characterized by the aggregation of proteins and resulting neuronal death. Approximately 2% of all ... -
Synthesis of amyloid-selective lysine acetylating agents, synthetic studies toward the total synthesis of (±)-caseabalansin A, and progress toward the total synthesis of (±)-isopalhinine A.
(2021-04-07)Repulsive electrostatic forces between prion-like proteins limit the aggregation between them. In medicinal chemistry, a protein’s net electrostatic charge (Z) is an uncommon target and compounds that increase a prion’s Z ... -
Rapid deuterium labeling and localization for structural elucidation of carbohydrates.
(2021-04-06)Carbohydrates are crucial components of life, serving a variety of cellular functions with broad implications. Characterization of carbohydrate structures is a significant step for understanding cell biology. While mass ... -
Approaches to understanding the cumulative effects of stressors on marine mammals.
(2020-12-03)In 2017, The National Academy of Sciences reported on the approaches to understanding the cumulative effects of stressors on marine mammals and suggested the use of baleen whale earplugs to evaluate both stress and stressors. ... -
Efforts toward an enantioselective total synthesis of (–)-oxazolomycin B and simplified chemical probes for proteomics studies; pharmacophore-directed retrosynthesis applied to gracilin A : simplified bioactive derivatives.
(2020-11-20)The oxazolomycins are bioactive peptide-polyketide hybrid natural products first isolated in 1985 by Uemura and co-workers from Streptomyces bacteria. Their complex structure and wide-ranging bioactivity against various ... -
Extending the boundaries of hydrogen/deuterium exchange (HDX) to glycans by establishing the fundamentals of in-electrospray ionization HDX.
(2020-11-23)The main focus of this dissertation is the development of in-electrospray ionization (ESI) - hydrogen/deuterium exchange (HDX) - mass spectrometry (MS) methodologies to elucidate carbohydrate structures. While HDX-MS is a ... -
Photo-catalyzed, β-selective hydrocarboxylation of α,β-unsaturated esters with CO2 under flow for β-lactone synthesis; natural product derivatization with β-lactones, β-lactams toward ‘infinite’ binders; enantioselective synthesis of medium-sized lactams employing chiral α,β-unsaturated acylammonium salts.
(2020-10-29)β-Lactones and β-lactams are privileged structural motifs found in both therapeutics and natural products. The annulation of relatively small-sized β-lactones and β-lactams onto alkenes are expected to exert minimal steric ...
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