Browsing Theses/Dissertations - Chemistry & Biochemistry by Title
Now showing items 78-86 of 86
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Targeting cancer through inhibition of cathepsin B by non-peptidic small molecule thiosemicarbazones and disruption of pre-existing vasculature by colchicine-like benzosuberene analogues.
(, 2014-01-28)Cancer is a leading cause of death in men and women under in the United States and is characterized by uncontrolled cellular proliferation and migration (metastasis) which can impinge on surrounding organs, modify ordinary ... -
Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents.
(, 2012-08-08)Targeting the vascular network that supplies a tumor with oxygen and nutrients is a viable methodology for the treatment of cancer. With the discovery of the combretastatin extended family of compounds in the late 1970's ... -
The gas chromatographic separation properties of azulene and the synthesis and characterization of bulky bis-pyrazolylpyridine metal-ligand complexes.
(2018-01-04)The separation of complex mixtures of molecules is vital to the conduct and understanding of modern chemical research. In this work, new materials for gas chromatographic separations are developed, evaluated, and discussed. ... -
Total syntheses of (+)- and (–)- tetrapetalones A and C.
(2018-02-27)The total syntheses of polyketide natural products (–)-/(+)-tetrapetalone A and (–)-/(+)-tetrapetalone C are described. In 2003, during their pursuit for novel lipoxygenase inhibitors, Hirota and coworkers reported the ... -
Ultra-sensitive instrumentation in the UV-Vis-NIR spectral region with application on overtone spectroscopy.
(2015-07-24)Fourier transform infrared spectroscopy (FT-IR) is a technique widely used in molecular spectroscopy. Technology advancements are such that FT-IR spectrometers can measure vibrational transitions occurring well within the ... -
Under confinement : molecular dynamics investigations of ions and molecules in nanopores and at nanoscale interfaces.
(2018-07-20)The behavior of molecules in nanopores and at nanoscale interfaces are of fundamental importance in chemical applications such as electrical energy storage and water desalination. Investigations into carbon based structures ... -
Unimolecular decomposition kinetics at resolved internal energies.
(2016-12-01)The kinetic behavior of microcanonical unimolecular decomposition reactions involving clusters formed by the electrostatic interaction between transition metal cations and simple organic molecules has been measured at ... -
Unique fragmentation of pentafluorobenzylic alcohols and the use of modified injection port liners in the gas chromatographic-based screening for catalytic activity.
(2006-02-16)An unprecedented reaction, the base-catalyzed fragmentation of pentafluorobenzylic alcohols, was investigated. Studies on a variety of C6F5-derived alcohols show that a dual reaction pathway occurs in mixed solvent systems ... -
Vibrational spectroscopy in cryogenic solutions: application of thermal lensing and Fourier transform techniques to the study of molecular C-H overtone transitions.
(2007-01-22)This dissertation explores the application of thermal lensing to vibrational overtone spectroscopy in cryosolutions. Specifically, C-H (delta v = 6) overtone spectra of hydrocarbons dissolved in liquefied rare gases are ...