Browsing Theses/Dissertations - Chemistry & Biochemistry by Title
Now showing items 1-20 of 81
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Advanced ion mobility - mass spectrometry methods for the analysis of compositionally complex mixtures.
(2016-02-02)Enormous analytical challenges are involved in the analysis of compositionally complex samples such as biomass-derived products and crude oils. In this dissertation mass spectrometry (MS)-based novel strategies for the ... -
Aggregation of Cu, Zn superoxide dismutase in amyotrophic lateral sclerosis : kinetic, mechanistic, and therapeutic approaches.
(2017-10-31)Investigating in vitro kinetics of protein aggregation using high-throughput microplate-based assays provides open venues for obtaining valuable information regarding mechanism(s) of pathogenesis of protein aggregates in ... -
Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
(, 2014-06-11)The rate at which pathogenic bacteria are gaining antibiotic resistance has become increasingly alarming. Major contributors of this antibiotic resistance in microbes are a class of enzymes known as β-lactamases. These ... -
Chemical kinetics and dynamics of M+(organic) molecules using single photon initiated dissociative rearrangement reactions (SPIDRR) measurements.
(2018-07-17)Gas-phase studies are important to many areas of science and technology. The ability to prepare molecular species in an environment devoid of complexities present in the condensed phase allows for high resolution measurement ... -
Chemistry, electrochemistry and electron transfer induced reactions of cobalt complexes with fluorinated ligands.
(2008-03-03)The chemical or electrochemical reduction of the trifluoroacetyl complex CF3COCo(CO)3PPh3 involves a single electron transfer yielding trifluoromethyl radical and an anionic cobalt carbonyl complex. The mechanism is ... -
Chemometric modeling of UV-visible and LC-UV data for prediction of hydrolysate fermentability and identification of inhibitory degradation products.
(, 2011-12-19)Production of ethanol from lignocellulosic biomass requires a pretreatment step to liberate fermentable sugars trapped within the plant. During pretreatment, lignin and some sugars undergo degradation to form compounds ... -
Construction and calibration of a custom time-of-flight mass spectrometer and its use in measuring the reaction kinetics of transition metal ion-organic interactions.
(2009-09-03)A unique instrument was constructed and used to generate and interrogate jet cooled neutrals, ions and their respective clusters. The instrument is a result of the artful marriage of supersonic expansions combined with ... -
Coordination chemistry of novel multifunctional pyridylphosphine ligands.
(2015-07-29)Coordination complexes with ligands that incorporate multiple donor moieties have been of particular interest due to the unique and diverse characteristics they can possess. In particular, phosphine- and/or nitrogen-based ... -
Copper ionophores induce autophagy in melanoma cells.
(, 2013-09-16)Malignant melanoma is a particularly aggressive form of skin cancer, for which the only current treatment option is excision. As melanoma is an inherently antiapoptotic model of cancer, other avenues of cell death were ... -
Decarbonylation, reductive electrochemistry and x-ray crystal structures of some rhodium diphosphine acyl complexes.
(2011-01-05)Acyl complexes of rhodium(III) with chelating diphosphine ligands (P-P = 1,3- bis(diphenylphosphino)propane and others) are well known for their stability toward decarbonylation. Various rhodium diphosphine acyl complexes ... -
Design and synthesis of combretastatin A-1 analogs, small molecule vascular disrupting agents, and bioreductive triggers as potential therapeutic agents for the treatment of cancer.
(2011-01-05)Cancer is the second leading cause of death in the United States with over 550,000 deaths in 2009 and a devastating 7.9 million deaths worldwide in 2007. Vascular disrupting agents (VDAs) represent a novel method developed ... -
Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
(2007-03-08)Cancer remains a deadly affliction for millions across the United States, and the number of new cases is only expected to rise in the years to come. In the field of anticancer research, vascular disrupting agents (VDAs) ... -
Design and synthesis of functionalized small-molecule inhibitors of cathepsins L and K.
(, 2012-08-08)Inhibition of a class of cysteine proteases known as the cathepsins has received increasing attention in recent years, since these enzymes play key roles in cancer metastasis. Cathepsins B, K, and L have been of particular ... -
Design and synthesis of non-peptidic thiosemicarbazone derivatives as inhibitors of cathepsins L and K.
(2012-11-29)Cathepsin L, a member of the lysosome cysteine proteases, is ubiquitously expressed in tissue and is responsible for protein turnover. An overexpression of cathepsin L by certain tumor types is associated with enhanced ... -
Design and synthesis of novel β-cyclodextrins and their application as chiral stationary phases for gas chromatography.
(2011-01-05)Enantiomers can be directly separated only with use of systems containing a chiral selector. Cyclodextrins (CDs) and modified cyclodextrins have been used as chiral selectors for their ability to form host-guest complexes ... -
Design and synthesis of potential serotonin-selective reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors for the treatment of depression.
(2010-10-08)Depression is a common disease characterized by feelings of deep sadness, guiltiness, loss of interest in once pleasurable activities, and thoughts of self-harm among others. Affecting an estimated 121 million people ... -
Design, synthesis and biological evaluation of new anti-Cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of Chagas.
(2006-05-29)In an effort to combat cancer, the development of a relatively new type of anti-cancer drugs known as vascular disrupting agents (VDAs) seems to be a promising clinical approach. VDAs selectively interfere with blood flow ... -
Design, synthesis and biological evaluation of novel serotonin reuptake inhibitors and novel derivatives of a nitrogen-containing combretastatin analog.
(2006-10-13)Depression is a common and serious illness that affects one out of every ten Americans each year. Since the 1980's, selective serotonin reuptake inhibitors (SSRIs) have been the pharmaceuticals of choice for the treatment ... -
Design, synthesis and evaluation of di-nitrogen derivatives of combretastatin and novel cruzain inhibiting compounds for the treatment of Chagas disease.
(2008-03-03)Over the past years cancer statistics have continued to rise to the point that the World Health Organization said that in 2005 cancer was leading cause of death worldwide. Years of research have resulted in many new ... -
The design, synthesis, and biological evaluation of indole-based anticancer agents.
(, 2014-01-28)Solid tumors depend on a vascular network that delivers nutrients and oxygen, thus selectively targeting the developed tumor vasculature represents a feasible strategy for the treatment of cancer. Both small-molecules and ...