Browsing Theses/Dissertations - Chemistry & Biochemistry by Title
Now showing items 1-20 of 116
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A methodology for chemoselective carbonyl ylide formation, total synthesis of (±)-aspergilline A, cyclopiamide A and speradine E and progress toward the total synthesis of (±)-isopalhinine A.
(2018-10-12)In 2001, the total synthesis of (±)-epoxysorbicillinol was completed by Wood and coworkers. This work featured as the key step a Rh(II) catalyzed carbonyl ylide formation and subsequent dipolar cycloaddition of a diazomalonate ... -
Advanced ion mobility - mass spectrometry methods for the analysis of compositionally complex mixtures.
(2016-02-02)Enormous analytical challenges are involved in the analysis of compositionally complex samples such as biomass-derived products and crude oils. In this dissertation mass spectrometry (MS)-based novel strategies for the ... -
Aggregation of Cu, Zn superoxide dismutase in amyotrophic lateral sclerosis : kinetic, mechanistic, and therapeutic approaches.
(2017-10-31)Investigating in vitro kinetics of protein aggregation using high-throughput microplate-based assays provides open venues for obtaining valuable information regarding mechanism(s) of pathogenesis of protein aggregates in ... -
Application of ab initio theory to the chemistry of ultrathin films.
(2018-07-11)In this work, we investigate a number of important nanosheets, e.g., graphene, haeckelites, and titanium disulfide for the expressed purpose of tuning the electronic ground state properties. We employ condensed matter ... -
Approaches to understanding the cumulative effects of stressors on marine mammals.
(2020-12-03)In 2017, The National Academy of Sciences reported on the approaches to understanding the cumulative effects of stressors on marine mammals and suggested the use of baleen whale earplugs to evaluate both stress and stressors. ... -
Cavity ring down and thermal lens techniques applied to vibrational spectroscopy of gases and liquids.
(2017-06-15)Infrared (IR) and near-infrared (NIR) region gas temperature sensors have been used in the past because of its non-intrusive character and fast time response. In this dissertation cavity ring down (CRD) absorption of oxygen ... -
Characterization of fundamental adsorption behavior of pesticides on polar organic chemical integrative sampler (POCIS).
(2019-04-03)Determination of accurate time weighted average concentrations (TWACs) of chemicals in water using polar organic chemical integrative sampler (POCIS) is still unsatisfactory, due to the limited understanding of environmental ... -
Characterization of human IL-10-producing regulatory B cells.
(2019-08-15)Regulatory B cells (Bregs) play a pivotal role in the maintenance of immune tolerance. Such critical roles of Bregs have been demonstrated in multiple disease types, including inflammatory diseases, organ transplantation, ... -
Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
(, 2014-06-11)The rate at which pathogenic bacteria are gaining antibiotic resistance has become increasingly alarming. Major contributors of this antibiotic resistance in microbes are a class of enzymes known as β-lactamases. These ... -
Characterization of the single photon initiated dissociative rearrangement reaction (SPIDRR) technique and its application in the study of transition metal cation bound organic cluster reactions.
(2018-07-09)The study of gas-phase ion-molecule reactions has been influential in the investigation of transition metal mediated bond activation and catalysis. This research has recently been advanced by a new method designated the ... -
Chemical kinetics and dynamics of M+(organic) molecules using single photon initiated dissociative rearrangement reactions (SPIDRR) measurements.
(2018-07-17)Gas-phase studies are important to many areas of science and technology. The ability to prepare molecular species in an environment devoid of complexities present in the condensed phase allows for high resolution measurement ... -
Chemistry, electrochemistry and electron transfer induced reactions of cobalt complexes with fluorinated ligands.
(2008-03-03)The chemical or electrochemical reduction of the trifluoroacetyl complex CF3COCo(CO)3PPh3 involves a single electron transfer yielding trifluoromethyl radical and an anionic cobalt carbonyl complex. The mechanism is ... -
Chemometric modeling of UV-visible and LC-UV data for prediction of hydrolysate fermentability and identification of inhibitory degradation products.
(, 2011-12-19)Production of ethanol from lignocellulosic biomass requires a pretreatment step to liberate fermentable sugars trapped within the plant. During pretreatment, lignin and some sugars undergo degradation to form compounds ... -
Computational study of glycopeptide antibiotics interactions with Staphylococcus aureus peptidoglycan.
(2021-08-04)Staphylococcus aureus is generally known for its ability to acquire resistance to any antibiotic. Methicillin-resistant S. aureus is one of the leading etiological agents responsible for the hospital- and community-acquired ... -
Construction and calibration of a custom time-of-flight mass spectrometer and its use in measuring the reaction kinetics of transition metal ion-organic interactions.
(2009-09-03)A unique instrument was constructed and used to generate and interrogate jet cooled neutrals, ions and their respective clusters. The instrument is a result of the artful marriage of supersonic expansions combined with ... -
Coordination chemistry of novel multifunctional pyridylphosphine ligands.
(2015-07-29)Coordination complexes with ligands that incorporate multiple donor moieties have been of particular interest due to the unique and diverse characteristics they can possess. In particular, phosphine- and/or nitrogen-based ... -
Copper ionophores induce autophagy in melanoma cells.
(, 2013-09-16)Malignant melanoma is a particularly aggressive form of skin cancer, for which the only current treatment option is excision. As melanoma is an inherently antiapoptotic model of cancer, other avenues of cell death were ... -
Decarbonylation, reductive electrochemistry and x-ray crystal structures of some rhodium diphosphine acyl complexes.
(2011-01-05)Acyl complexes of rhodium(III) with chelating diphosphine ligands (P-P = 1,3- bis(diphenylphosphino)propane and others) are well known for their stability toward decarbonylation. Various rhodium diphosphine acyl complexes ... -
Design and activation of small organic molecules for localized immunosuppression.
(2021-08-27)Since the implementation of the Edmonton Protocol in the early 2000s, many efforts have been made to further improve the long-term viability of transplanted islets in recipients with type 1 diabetes mellitus. These efforts ... -
Design and implementation of a custom imaging mass spectrometer.
(2019-07-26)Mass spectrometry (MS) has been demonstrated as one of the most robust and capable analytical tools for chemical analysis. As such, MS has found application across practically every field of science today. One notable area ...