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Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
(2008-06-16)
Vascular disruption is an innovative method for treating cancer. By selectively altering the endothelial cells of tumor vasculature, the tumor can be destroyed by oxygen deprivation and starvation. The combretastatin ...
High-performance liquid chromatographic methods for quantitative assessment of degradation products and extractives in pretreated lignocellulose.
(Amsterdam : Elsevier B. V.Washington, D.C. : American Chemical Society., 2006)
Long-term economic, national security, and environmental concerns have motivated research into renewable fuels from lignocellulosic biomass. Among energy alternatives, biomass-derived ethanol represents one of the more ...
Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
(2007-03-08)
Cancer remains a deadly affliction for millions across the United States, and the number of new cases is only expected to rise in the years to come. In the field of anticancer research, vascular disrupting agents (VDAs) ...
Synthetic coenzymes for in vitro selection of DNA enzymes.
(2007-01-22)
Over the past 10 years a number of catalytically active single-stranded DNA molecules (deoxyribozymes) have been isolated from combinatorial libraries (pools) of randomized oligonucleotides. These enzyme-like DNAs customarily ...
Studies on bovine γ-glutamylamine cyclotransferase.
(2007-02-14)
The purification and study of proteins are cooperative processes because at least partially purified protein is needed in order to study its properties, and certain information about the protein's properties is required ...
Unique fragmentation of pentafluorobenzylic alcohols and the use of modified injection port liners in the gas chromatographic-based screening for catalytic activity.
(2006-02-16)
An unprecedented reaction, the base-catalyzed fragmentation of pentafluorobenzylic alcohols, was investigated. Studies on a variety of C6F5-derived alcohols show that a dual reaction pathway occurs in mixed solvent systems ...
Synthesis, characterization, and applications of redox-mediated ion exchangers.
(2007-12-04)
The technology for conversion of lignocellulosic biomass resources to fuels and chemicals has been under development for decades. There are many process configurations for conversion of biomass to ethanol, one of the ...
A novel spectropolarimeter for determiation of sucrose and other optically active samples.
(2006-07-25)
Polarimetry and spectropolarimetry are important tools in the sugar industry and pharmaceutical research. Polarimetric measurements cannot be performed on colored samples because the presence of color interferes with the ...
Luminescent supramolecular silver(I) coordination complexes of pyridyl-substituted phosphinites, phosphonites and amines.
(2006-05-28)
Interest in the design and synthesis of supramolecular metal-organic coordination polymers has increased exponentially in the last decade. This attraction comes along with advances in crystallographic instrumentation that ...
Inhibitors of human cathepsin L and cruzain as therapeutic agents.
(2009-04-01)
Increased human cathepsin L activity is linked to invasive and metastatic cancers where it promotes degradation of the extracellular matrix. This major cysteine protease found in cell lysosomes and secreted from tissues, ...