Browsing Institute of Biomedical Studies by Author "Baylor University. Institute of Biomedical Studies."
Now showing items 1-20 of 27
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Advancing chemical and biologically-based “Read across” through in silico, in vitro and in vivo techniques.
Connors, Kristin A. (, 2014-09-05)Read across approaches include data leveraging across chemicals or among biological scales of organization or species, and may focus limited resources to support chemical hazard and risk assessment. Sustainable molecular ... -
Analysis of inflammatory changes in human pancreatic islet cells.
Jackson, Andrew M. (2009-02-27)Pancreatic islet cell transplantation is a promising investigational research treatment for labile type 1 diabetes mellitus. However, several obstacles still exist to the implementation of clinical islet cell transplantation ... -
Anti-tumor activity of an oncolytic adenoviral construct expressing a small interfering RNA transgene.
Samuel, Shirley Kulangara. (Philadelphia, PA : American Association for Cancer Research., 2006-10-01)Cancer is a leading cause of mortality in the world today. Mutation in the K-ras oncogene is common in most human cancers. K-ras oncogene expression was specifically downregulated by 58.7% by K-ras silencing siRNA, and ... -
Automated sequence homology : using empirical correlations to create graph-based networks for the elucidation of protein relationships.
Bush, Stephen J. (2008-10-02)Identification of sequence homology has presented a formidable obstacle despite significant increases in both technological capability and detailed knowledge of genomes and proteomes. While PSI-BLAST remains the popular ... -
Comparative toxicity evaluations for polybrominated diphenyl ethers (PBDEs) : investigation of developmental toxicity, uptake and mechanisms of action in embryonic zebrafish (Danio rerio)
Usenko, Crystal Y. (, 2012-11-29)Recently, polybrominated diphenyl ethers (PBDEs) were banned due to extensive environmental contamination and potential health effects. There is little understanding of the comparative toxicity of individual congeners. ... -
Design, optimization, and evaluation of conditionally active gene therapy vectors.
Wood, David Rowe. (2008-06-09)It is the objective of this project to produce gene therapy vectors that are active and/or significantly up-regulated due to specific physiological conditions. The significance of such constructs is that it imparts a greater ... -
Development of an aptamer-based detection assay against Bacillus anthracis lethal factor and Escherichia coli.
Lahousse, Mieke. (, 2013-09-24)The impressive capacity of bacteria to adapt to their environment has led to the development of mechanisms that can convey resistance to currently FDA approved antibiotics. In an attempt to find a solution to the possibility ... -
Development of dendritic cell-based vaccines for the treatment of HIV-infected patients.
Cobb, Amanda J., 1979- (, 2011-09-14)Dendritic cells (DCs) are professional antigen-presenting cells of the immune system with the ability to induce and control T and B cells responses. Monocytes have been used as precursors to generate DC vaccines ex vivo. ... -
The effect of dietary folate deficiency and age on methylation metabolites, neurotransmitters, and behavior in mice.
Wasek, Brandi Lynn. (2011-01-05)Severe folate deficiency caused by inborn errors of metabolism has profound deleterious effects in the CNS such as mental retardation, psychiatric disorders, seizures and myelopathy. Mild folate deficiency, due to dietary ... -
Folding, dynamics and interaction studies of the Neuropeptide Y family.
Hegefeld, Wendy A. (, 2011-12-19)Detailed molecular knowledge of the complex dynamics of biological processes such as folding and the interaction with cellular membranes may greatly advance the treatment of human disease. The Neuropeptide Y family of ... -
Gamma Hydroxybutyrate (GHB): mechanisms of central nervous system toxicity.
Lyng, Eric E. (2006-07-31)Gamma Hydroxybutyrate (GHB) is an endogenous metabolite of gamma-aminobutyric acid (GABA) and a putative neurotransmitter found in mammalian brain. The illicit use of GHB is a growing health care concern in the U.S. Low ... -
Gene expression profiling to understand the alterations in the monocyte compartment of pediatric systemic lupus erythematosus.
Patel, Pinakeen Shankarbhai. (2008-06-11)Blood monocytes from SLE patients display DC function, as they are able to induce the proliferation of allogeneic T cells. Furthermore, sera from SLE patients induce healthy monocytes to differentiate into DCs. This ... -
Growth inhibition of human multiple myeloma cells by a conditional-replicative, oncolytic adenovirus armed with the CD154 (CD40-ligand) transgene.
Rodrigues, Margret S. (2007-03-08)Human multiple myeloma (MM) remains incurable despite successes in induction therapy. Based on our previous findings that treatment with the recombinant CD40L protein inhibited the growth of CD40+ human myeloma cell ... -
Humanized mice to test vaccination against influenza virus via dendritic cells.
Yu, Chun-I, 1975- (2008-06-11)Critical to the development of human vaccines is the availability of in vivo models of the human immune system that permit testing of vaccine efficacy. Here,we used NOD-SCID-β²m-/- immunodeficient mice which, when engrafted ... -
Identification of dysregulated miRNA targets in human prostate cancer.
Chen, Po-hsun. (2010-02-02)MicroRNAs (miRNAs) are small, non-coding RNAs (18~24 nt) that regulate diverse cell functions in mammalian cells, including proliferation, differentiation, metabolism, stress resistance, and death. There is increasing ... -
Inhibition of β-lactamase I from Bacillus cereus by ssDNA.
Foster, Taylor Ann. (, 2011-09-14)Inhibitors of β-lactamases are important to the treatment of infectious diseases when used in conjunction with a β-lactam antibiotic. Current inhibitors of β-lactamase such as clavulanic acid, sulbactam, and tazobactam ... -
Leveraging available data for contaminants of emerging concern to develop an understanding of environmental hazard.
Berninger, Jason P. (, 2011-09-14)Contaminants of emerging concern (CEC) are classes of compounds with relatively limited information available on environmental exposure, fate, and effects. The purpose of this research was to develop and test approaches ... -
Molecular mechanisms in low-serotonin induced mood and anxiety disorders.
Tran, Lee. (2010-10-08)The amygdala has been shown to be involved in both epilepsy and emotional disturbances such as in mood and anxiety disorders. It is suggested that anxiety and mood disorders may be the result of sub-seizure hyperexcitability ... -
A possible mechanistic role for microorganisms in the genesis of colorectal cancer.
Butcher, Lindsay D. (, 2013-09-24)Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. An estimated over 140,000 people will be diagnosed with CRC and over 50,000 people will die in 2013. CRC tumors develop ... -
The recombinant expression of two pollen allergens using plant-viral and yeast expression systems.
Moehnke, Marcie H. (2006-05-09)Allergic disease causes much distress within industrialized areas of the world, affecting approximately a quarter of the population in such areas. Current immunotherapy involves the administration of increasing concentrations ...