Theses/Dissertations - Biomedical Studies
Browse by
Recent Submissions
-
Peptidoglycome of gram-positive bacteria.
(2021-10-08)Our modern healthcare system faces imminent threats from multidrug-resistant pathogens due to their unprecedented increase in the frequency of infections in clinical environment compounded by the lack of novel antibiotic ... -
Plasmacytoid dendritic cell TLR7/9 response modulation through EGA and α-CD138 antibody.
(2021-05-28)Plasmacytoid dendritic cells (pDC) have the unique ability to produce an inordinate amount of type 1 interferon (IFN) and other cytokines in response to stimulation with pathogenic and self-nucleic acids mainly through the ... -
MISTR : a conserved MItochondrial STress Response network revealed by signatures of evolutionary conflict.
(2021-04-01)As pathogens manipulate host-encoded master regulators, we hypothesized that molecular scars of host-pathogen conflicts-such as signatures of rapid evolution and viral mimics-could lead to the discovery of novel cellular ... -
Impact of neuroinflammatory and mTOR signaling inhibition following flurothyl seizures on the acute development of autistic-like behavior in C57BL/6 mice.
(2020-03-13)Epilepsy is a common neurological disorder, with individuals having an increased susceptibility of seizures in the first few years of life. Children with epilepsy are at risk of developing a multitude of cognitive and ... -
Innovating recombinant production of short peptide targeted antimicrobial peptides utilizing clean purification in plants and E. coli bioreactors.
(2019-11-05)Antibiotic-resistant pathogens continue to become a pressing issue globally and current broad spectrum therapies fail to meet this challenge. Therapeutics equipped with targeting moieties would alleviate this issue without ... -
Statistical methods for high-throughput data integration : methodologies in disease research and drug discovery.
(2019-07-09)The wide application of high-throughput technologies in biomedical research calls for integrative approaches for data mining and knowledge discovery. Consequently, methodologies that deliver robust and systems integrations ... -
Towards less hazardous chemicals : identifying chemical bioactivity through fish behavioral profiles.
(2019-04-02)Because most chemicals in commerce lack empirical toxicology information, innovative approaches are needed to identify substances presenting elevated hazards and risks to public health and the environment. When larval fish ... -
Inhibition of TLR4 minimizes islet damage due to sterile inflammation and improves islet transplant outcomes.
(2018-06-01)Islet transplantation has emerged as an important treatment option for brittle type 1 diabetes and as an adjunct procedure after total pancreatectomy to prevent brittle diabetes. The efficacy and long-term function of islet ... -
Quantitative cellular and molecular imaging of the intact tumor microenvironment.
(2018-07-23)The causes underlying the extent and character of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity, host genotype, and the immune status of ... -
Electrostatic control of Cu, Zn superoxide dismutase aggregation in Amyotrophic Lateral Sclerosis : from lysine modification to interaction with lipid membranes.
(2018-07-20)Cu, Zn superoxide dismutase (SOD1) is a ubiquitous metalloprotein, which is responsible for protecting living cells from oxidative stress via disproportionation of superoxide ions. Misfolding and subsequent aggregation of ... -
Mechanism of C-type lectin receptor Dectin-1 and DC-ASGPR-mediated immune modulation.
(2018-03-23)Dendritic cells (DCs) are major antigen-presenting cells (APCs) and play a critical role in directing host immune responses towards either immunity or tolerance. C-type lectin receptors (CLRs) expressed on DCs not only ... -
Machine learning-assisted prediction of structure and function of cystine-stabilized peptides and optimization of expression in an E. coli system.
(2018-03-22)Cystine-stabilized peptides are promising prospects for the pharmaceutical industry as biologics. These peptides carry out a variety of useful functions which could be exploited to treat diseases and kill unwanted organisms. ... -
The chromatin accessibility signature of aging in human blood leukocytes stem from CD8+ T cells.
(2017-07-26)Human aging is linked to changes in immune function that contribute to decreased responses to pathogens and increased systemic inflammation. Human aging is also associated with profound epigenetic changes across cell types ... -
Evolution to pollution in Gulf killifish (Fundulus grandis) from Galveston Bay, TX, USA.
(2017-07-27)Anthropogenic contamination associated with industrial activity is a widespread and active threat to the stability of organisms. The Houston Ship Channel (HSC) is one example of a heavily impacted environment, where ... -
Preclinical characterization of small molecule compounds as therapeutics for cancer and Chagas’ disease : tumor vascular disrupting agents and cysteine protease inhibitors.
(2017-03-31)The purpose of this study was the pre-clinical exploration of specific small molecule compounds as vascular disrupting agents and cysteine protease inhibitors, targeted towards the development of therapeutic agents for the ... -
Immune profiles of allergic asthma patients treated with anti-IgE.
(2016-12-01)Asthma is a chronic inflammatory disease of the airways characterized by bronchial hyper-reactivity, mucus overproduction and airway remodeling and narrowing. Of the various phenotypes of asthma, by far the most common ... -
The utility of whole exome sequencing in the investigation of the genetic etiologies of leukodystrophies and genetic leukoencephalopathies.
(2016-08-03)Leukodystrophies and genetic leukoencephalopathies are diseases of the white matter in the central nervous system making up over 100 distinct genetic disorders, and their paradoxical heterogenic but overlapping clinical ... -
Superimposing status epilepticus on NS-PTEN haploinsufficient and wild type mice results in long-term changes in behavior.
(2016-07-29)Autism Spectrum Disorder (ASD) is a neurodevelopment disorder with a prevalence rate of approximately 1% in children. Epilepsy is another neurodevelopmental disorder with similar 1% prevalence in the US population. ... -
Plant-produced, trans-encapsidated, replicative viral nanoparticles as a vaccine platform.
(2016-08-01)Replicative virus-based vaccines provide potential solutions to avoid the natural deficits of traditional single-protein subunit vaccines. Unlike subunit vaccines, the infectious nature of viral particles can stimulate the ... -
Anti-CD47 targeting therapy for the treatment of colon and pancreas cancers.
(2016-03-10)CD47 is a “don’t eat me” signal over expressed on cancer cells inhibiting their engulfment by phagocytes. A novel monoclonal antibody, Hu5F9-G4, blocking CD47’s interaction with its ligand SIRPα allowed for phagocytosis ...
RSS 1.0