Browsing Theses/Dissertations - Biomedical Studies by Title
Now showing items 23-39 of 39
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Leveraging available data for contaminants of emerging concern to develop an understanding of environmental hazard.
(, 2011-09-14)Contaminants of emerging concern (CEC) are classes of compounds with relatively limited information available on environmental exposure, fate, and effects. The purpose of this research was to develop and test approaches ... -
Machine learning-assisted prediction of structure and function of cystine-stabilized peptides and optimization of expression in an E. coli system.
(2018-03-22)Cystine-stabilized peptides are promising prospects for the pharmaceutical industry as biologics. These peptides carry out a variety of useful functions which could be exploited to treat diseases and kill unwanted organisms. ... -
Mechanism of C-type lectin receptor Dectin-1 and DC-ASGPR-mediated immune modulation.
(2018-03-23)Dendritic cells (DCs) are major antigen-presenting cells (APCs) and play a critical role in directing host immune responses towards either immunity or tolerance. C-type lectin receptors (CLRs) expressed on DCs not only ... -
Molecular mechanisms in low-serotonin induced mood and anxiety disorders.
(2010-10-08)The amygdala has been shown to be involved in both epilepsy and emotional disturbances such as in mood and anxiety disorders. It is suggested that anxiety and mood disorders may be the result of sub-seizure hyperexcitability ... -
A possible mechanistic role for microorganisms in the genesis of colorectal cancer.
(, 2013-09-24)Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. An estimated over 140,000 people will be diagnosed with CRC and over 50,000 people will die in 2013. CRC tumors develop ... -
Quantitative cellular and molecular imaging of the intact tumor microenvironment.
(2018-07-23)The causes underlying the extent and character of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity, host genotype, and the immune status of ... -
The recombinant expression of two pollen allergens using plant-viral and yeast expression systems.
(2006-05-09)Allergic disease causes much distress within industrialized areas of the world, affecting approximately a quarter of the population in such areas. Current immunotherapy involves the administration of increasing concentrations ... -
Reprogramming T cell specific immune responses to Cyclin B1 in breast cancer patients using a TLR 8/7 agonist.
(, 2012-08-08)Cyclin B1 is a cell cycle regulatory protein aberrantly overexpressed in a number of cancers, including breast cancer. While the current standards of care for breast cancer are sometimes curative, many patients suffer ... -
Reprogramming the immune environment in breast cancer via dendritic cells.
(, 2013-09-24)Breast cancer is the most common cancer among American women. The current therapies are not curative for some forms of breast cancer, especially breast cancers that do not express the growth factor and hormone receptors ... -
Respiratory Syncytial Virus triggers immune tolerance through induction of tolerogenic dendritic cells and expansion of regulatory T cells.
(2010-06-23)Dendritic cells have the ability to control the balance between immunity and tolerance. Upon viral exposure, Dendritic Cells (DCs) steadily detect pathogens and exert their antigen presentation function to induce adaptive ... -
RNAi screen for novel components in Caenorhabditis elegans ovulation and fertility.
(2010-02-02)The intercellular and intracellular signaling pathways elucidated through research on the nematode C. elegans provide valuable information on the communication systems throughout all organisms. Through the use of RNA ... -
Structural analysis of biomolecules using ion mobility and mass spectrometry : exploration of ion rearrangements and conformations.
(2016-03-21)Early diagnosis of diseases is dependent on the development of reliable physiological and biochemical tests. The most precise medical tests employ analytical methods to identify specific molecules (“biomarkers”) or molecular ... -
Structure, dynamics, and interactions of Angiotensin family of peptides with functional implications.
(, 2011-12-19)We present a study of structural analysis and reorientational dynamics of the angiotensin family of peptides. AngI is a decapeptide that acts as a precursor to the octapeptide, AngII in the Renin Angiotensin Aldosterone ... -
Targeting the immune microenvironment to treat breast cancer.
(, 2014-06-11)In tumor microenvironment, the crosstalk between infiltrating inflammatory cells and tumor cells creates a cytokine milieu which can promote both oncogenesis and tumor rejection. We have found an IL-13 dominant cytokine ... -
The chromatin accessibility signature of aging in human blood leukocytes stem from CD8+ T cells.
(2017-07-26)Human aging is linked to changes in immune function that contribute to decreased responses to pathogens and increased systemic inflammation. Human aging is also associated with profound epigenetic changes across cell types ... -
To giveth and taketh away : determination of taurine's protective role during ethanol withdrawal through supplementation and depletion paradigms.
(2009-04-01)The β-amino acid taurine, whose primary physiological roles involve osmoregulation and calcium modulation, exists as one of the most concentrated amino acids in the mammalian brain. As a neuroinhibitor and neuromodulator, ... -
Towards less hazardous chemicals : identifying chemical bioactivity through fish behavioral profiles.
(2019-04-02)Because most chemicals in commerce lack empirical toxicology information, innovative approaches are needed to identify substances presenting elevated hazards and risks to public health and the environment. When larval fish ...