Browsing Theses/Dissertations - Biomedical Studies by Title
Now showing items 34-39 of 39
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Structural analysis of biomolecules using ion mobility and mass spectrometry : exploration of ion rearrangements and conformations.
(2016-03-21)Early diagnosis of diseases is dependent on the development of reliable physiological and biochemical tests. The most precise medical tests employ analytical methods to identify specific molecules (“biomarkers”) or molecular ... -
Structure, dynamics, and interactions of Angiotensin family of peptides with functional implications.
(, 2011-12-19)We present a study of structural analysis and reorientational dynamics of the angiotensin family of peptides. AngI is a decapeptide that acts as a precursor to the octapeptide, AngII in the Renin Angiotensin Aldosterone ... -
Targeting the immune microenvironment to treat breast cancer.
(, 2014-06-11)In tumor microenvironment, the crosstalk between infiltrating inflammatory cells and tumor cells creates a cytokine milieu which can promote both oncogenesis and tumor rejection. We have found an IL-13 dominant cytokine ... -
The chromatin accessibility signature of aging in human blood leukocytes stem from CD8+ T cells.
(2017-07-26)Human aging is linked to changes in immune function that contribute to decreased responses to pathogens and increased systemic inflammation. Human aging is also associated with profound epigenetic changes across cell types ... -
To giveth and taketh away : determination of taurine's protective role during ethanol withdrawal through supplementation and depletion paradigms.
(2009-04-01)The β-amino acid taurine, whose primary physiological roles involve osmoregulation and calcium modulation, exists as one of the most concentrated amino acids in the mammalian brain. As a neuroinhibitor and neuromodulator, ... -
Towards less hazardous chemicals : identifying chemical bioactivity through fish behavioral profiles.
(2019-04-02)Because most chemicals in commerce lack empirical toxicology information, innovative approaches are needed to identify substances presenting elevated hazards and risks to public health and the environment. When larval fish ...