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Humanized mice to test vaccination against influenza virus via dendritic cells.
(2008-06-11)
Critical to the development of human vaccines is the availability of in vivo models of the human immune system that permit testing of vaccine efficacy. Here,we used NOD-SCID-β²m-/- immunodeficient mice which, when engrafted ...
Design, optimization, and evaluation of conditionally active gene therapy vectors.
(2008-06-09)
It is the objective of this project to produce gene therapy vectors that are active and/or significantly up-regulated due to specific physiological conditions. The significance of such constructs is that it imparts a greater ...
Gene expression profiling to understand the alterations in the monocyte compartment of pediatric systemic lupus erythematosus.
(2008-06-11)
Blood monocytes from SLE patients display DC function, as they are able to induce the proliferation of allogeneic T cells. Furthermore, sera from SLE patients induce healthy monocytes to differentiate into DCs. This ...
Growth inhibition of human multiple myeloma cells by a conditional-replicative, oncolytic adenovirus armed with the CD154 (CD40-ligand) transgene.
(2007-03-08)
Human multiple myeloma (MM) remains incurable despite successes in induction
therapy. Based on our previous findings that treatment with the recombinant CD40L
protein inhibited the growth of CD40+ human myeloma cell ...
To giveth and taketh away : determination of taurine's protective role during ethanol withdrawal through supplementation and depletion paradigms.
(2009-04-01)
The β-amino acid taurine, whose primary physiological roles involve osmoregulation and calcium modulation, exists as one of the most concentrated amino acids in the mammalian brain. As a neuroinhibitor and neuromodulator, ...
Gamma Hydroxybutyrate (GHB): mechanisms of central nervous system toxicity.
(2006-07-31)
Gamma Hydroxybutyrate (GHB) is an endogenous metabolite of gamma-aminobutyric acid (GABA) and a putative neurotransmitter found in mammalian brain. The illicit use of GHB is a growing health care concern in the U.S. Low ...
The recombinant expression of two pollen allergens using plant-viral and yeast expression systems.
(2006-05-09)
Allergic disease causes much distress within industrialized areas of the world, affecting approximately a quarter of the population in such areas. Current immunotherapy involves the administration of increasing concentrations ...
Analysis of inflammatory changes in human pancreatic islet cells.
(2009-02-27)
Pancreatic islet cell transplantation is a promising investigational research treatment for labile type 1 diabetes mellitus. However, several obstacles still exist to the implementation of clinical islet cell transplantation ...
Anti-tumor activity of an oncolytic adenoviral construct expressing a small interfering RNA transgene.
(Philadelphia, PA : American Association for Cancer Research., 2006-10-01)
Cancer is a leading cause of mortality in the world today. Mutation in the K-ras oncogene is common in most human cancers. K-ras oncogene expression was specifically downregulated by 58.7% by K-ras silencing siRNA, and ...
Automated sequence homology : using empirical correlations to create graph-based networks for the elucidation of protein relationships.
(2008-10-02)
Identification of sequence homology has presented a formidable obstacle despite significant increases in both technological capability and detailed knowledge of genomes and proteomes. While PSI-BLAST remains the popular ...