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Towards less hazardous chemicals : identifying chemical bioactivity through fish behavioral profiles.
(2019-04-02)
Because most chemicals in commerce lack empirical toxicology information, innovative approaches are needed to identify substances presenting elevated hazards and risks to public health and the environment. When larval fish ...
Molecular mechanisms in low-serotonin induced mood and anxiety disorders.
(2010-10-08)
The amygdala has been shown to be involved in both epilepsy and emotional disturbances such as in mood and anxiety disorders. It is suggested that anxiety and mood disorders may be the result of sub-seizure hyperexcitability ...
RNAi screen for novel components in Caenorhabditis elegans ovulation and fertility.
(2010-02-02)
The intercellular and intracellular signaling pathways elucidated through research on the nematode C. elegans provide valuable information on the communication systems throughout all organisms. Through the use of RNA ...
Investigating the role of novel gene -C20orf197.
(2016-04-05)
The C20orf197 gene which is on chromosome 20 open reading frame 197, was sequenced at least 15 years ago, but even today, it still remains uncharacterised for the public. Meanwhile, over the last few decades it has become ...
The chromatin accessibility signature of aging in human blood leukocytes stem from CD8+ T cells.
(2017-07-26)
Human aging is linked to changes in immune function that contribute to decreased responses to pathogens and increased systemic inflammation. Human aging is also associated with profound epigenetic changes across cell types ...
Respiratory Syncytial Virus triggers immune tolerance through induction of tolerogenic dendritic cells and expansion of regulatory T cells.
(2010-06-23)
Dendritic cells have the ability to control the balance between immunity and tolerance. Upon viral exposure, Dendritic Cells (DCs) steadily detect pathogens and exert their antigen presentation function to induce adaptive ...
Folding, dynamics and interaction studies of the Neuropeptide Y family.
(, 2011-12-19)
Detailed molecular knowledge of the complex dynamics of biological processes such as folding and the interaction with cellular membranes may greatly advance the treatment of human disease. The Neuropeptide Y family of ...
Quantitative cellular and molecular imaging of the intact tumor microenvironment.
(2018-07-23)
The causes underlying the extent and character of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity, host genotype, and the immune status of ...
Electrostatic control of Cu, Zn superoxide dismutase aggregation in Amyotrophic Lateral Sclerosis : from lysine modification to interaction with lipid membranes.
(2018-07-20)
Cu, Zn superoxide dismutase (SOD1) is a ubiquitous metalloprotein, which is responsible for protecting living cells from oxidative stress via disproportionation of superoxide ions. Misfolding and subsequent aggregation of ...
Anti-CD47 targeting therapy for the treatment of colon and pancreas cancers.
(2016-03-10)
CD47 is a “don’t eat me” signal over expressed on cancer cells inhibiting their engulfment by phagocytes. A novel monoclonal antibody, Hu5F9-G4, blocking CD47’s interaction with its ligand SIRPα allowed for phagocytosis ...