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Design, optimization, and evaluation of conditionally active gene therapy vectors.
It is the objective of this project to produce gene therapy vectors that are active and/or significantly up-regulated due to specific physiological conditions. The significance of such constructs is that it imparts a greater ...
Growth inhibition of human multiple myeloma cells by a conditional-replicative, oncolytic adenovirus armed with the CD154 (CD40-ligand) transgene.
Human multiple myeloma (MM) remains incurable despite successes in induction therapy. Based on our previous findings that treatment with the recombinant CD40L protein inhibited the growth of CD40+ human myeloma cell ...