The effects of creatine ethyl ester supplementation combined with resistance training on body composition, muscle mass and performance, and intramuscular creatine uptake in males.

Date

2008-08

Authors

Spillane, Micheil Brian (Mike).

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Worldwide access

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Abstract

Creatine monohydrate has become one of the most popular ingested nutritional supplements due to its potential enhancement of athletic performance. Creatine absorption from the serum into skeletal muscle occurs through the utilization of a membrane-spanning protein, CreaT1. Numerous creatine formulations have been developed primarily to maximize creatine absorption. Creatine ethyl ester (CEE) has been chemically modified by adding an ester group and is thought to increase creatine bio-availability by by-passing the CreaT1. This study examined how a seven week supplementation regimen with CEE affected body composition, muscle mass and performance, whole body creatine retention, as well physiological and molecular adaptations, associated with creatine uptake in nonresistance-trained males following a resistance-training program. Results demonstrated that CEE did not show any additional benefit to increases in muscle strength/performance or a significant increase in total muscle creatine when compared to creatine monohydrate or placebo. CEE supplementation did show a large increase in creatinine levels throughout the study.

Description

Includes bibliographical references (p. 108-112)

Keywords

Creatine -- Physiological effect., Creatine -- Bioavailability., Muscle strength., Dietary supplements -- Physiological effect., Isometric exercise -- Physiological aspects., Musculoskeletal system -- Physiology.

Citation