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    GABA Stimulates Aldosterone Production In Intact Zona Glomerulosa Cells in Fetal Bovine Adrenal Glands

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    Honors College Agreement Form Signed.pdf (651.5Kb)
    Sai Achi thesis final version.pdf (1.367Mb)
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    Date
    2013-05-24
    Author
    Achi, Sai S.
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    Abstract
    Aldosterone is a steroid hormone produced in the adrenal cortex. It is mainly used in regulating ion movement such as Na+ and K+ via Na+/K+ pumps and thus it regulates mean arterial pressure. GABA (Gamma Amino Butyric Acid) is an inhibitory neurotransmitter that is found predominately in the central nervous system (CNS). This study aims to understand the effects of GABA on the aldosterone production in intact zona glomerulosa cells in fetal bovine adrenal glands. An Enzyme-Linked Immunosorbent Assay (ELISA) test was used to assess the effects of GABA on aldosterone production. GABA was given to an experimental group in varying concentrations of: 1.4 micromoles/ml, 2.8 micromoles/ml, and 5.6 micromoles/ml. It was observed that the aldosterone production increased at each concentration: 1.4 micromoles/ml increased by 7.85752% (with p=0.00014), 2.8 micromoles/ml increased by 4.81063% (with p=0.00012), and 5.6 micromoles/ml increased by 3.82624% (with p=0.00364). The data indicate that a dose dependent curve relationship exists as the GABA concentration increased and the aldosterone production increased.
    URI
    http://hdl.handle.net/2104/8632
    Department
    Business Administration.
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    Copyright © Baylor® University All rights reserved. Legal Disclosures.
    Baylor University Waco, Texas 76798 1-800-BAYLOR-U
    Baylor University Libraries | One Bear Place #97148 | Waco, TX 76798-7148 | 254.710.2112 | Contact: libraryquestions@baylor.edu
    If you find any errors in content, please contact librarywebmaster@baylor.edu
    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    TDL
    Theme by 
    Atmire NV