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    Kinetic Studies of Thiosemicarbazone Inhibitors of Cruzain, a Validated Target of Cruzain

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    Access changed 8/25/15.
    Date
    2013-05-24
    Author
    Guillory, Joseph
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    Abstract
    Chagas’ disease is caused by the flagellate protozoan Trypanosoma cruzi. As determined by the World Health Organization, effective therapeutic medications are needed for the treatment of Chagas’ disease. Cruzain, a powerful cysteine protease involved in cell invasion, immune evasion, and metabolism of the T. cruzi parasite, is a validated target for the disease. A number of thiosemicarbazone derivatives are inhibitors of cruzain. In this study, the kinetic mechanism of a potent thiosemicarbazone inhibitor of cruzain was investigated. A microplate reader using a 96-well plate format was used to perform fluorometric assays. Progress curves provided evidence that this thiosemicarbazone compound is a time-dependent inhibitor of cruzain. This was a collaborative study between the Trawick and Pinney groups at Baylor University.
    URI
    http://hdl.handle.net/2104/8656
    Department
    Biology.
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    Copyright © Baylor® University All rights reserved. Legal Disclosures.
    Baylor University Waco, Texas 76798 1-800-BAYLOR-U
    Baylor University Libraries | One Bear Place #97148 | Waco, TX 76798-7148 | 254.710.2112 | Contact: libraryquestions@baylor.edu
    If you find any errors in content, please contact librarywebmaster@baylor.edu
    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    TDL
    Theme by 
    Atmire NV