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    Design and Synthesis of Functionalized Thiosemicarbazone Analogues as Potential Anti-metastatic Agents

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    Date
    2013-05-24
    Author
    Cody, Andrew
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    Abstract
    Metastasis is often the ultimate cause of death among cancer patients. An emerging target in the treatment of metastasis is cathepsin L which facilitates the degradation of the extracellular matrix thereby providing a pathway for the movement of cancer cells to secondary locations in the body from the primary tumor. A variety of potent small-molecule cathepsin L inhibitors bearing the thiosemicarbazone moiety have been discovered through the collaboration of the Pinney Research Group and Trawick Research Group at Baylor University. A compound known as KGP94 is among the more potent inhibitors discovered and has been re-synthesized for further studies. The majority of thiosemicarbazone containing inhibitors of cathepsin L are asymmetrical and prone to isomerization about the imine bond of the thiosemicarbazone functional group. Since isomerization may interfere with the ability of these compounds to inhibit cathespin L, a series of symmetrical thiosemicarbazone analogues was prepared and evaluated as inhibitors of cathepsin L.
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    http://hdl.handle.net/2104/8698
    Department
    Chemistry.
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    Copyright © Baylor® University All rights reserved. Legal Disclosures.
    Baylor University Waco, Texas 76798 1-800-BAYLOR-U
    Baylor University Libraries | One Bear Place #97148 | Waco, TX 76798-7148 | 254.710.2112 | Contact: libraryquestions@baylor.edu
    If you find any errors in content, please contact librarywebmaster@baylor.edu
    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
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    Atmire NV