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dc.contributor.advisorBrooks, Bryan W.
dc.contributor.authorDreier, David
dc.contributor.otherBaylor University.en_US
dc.contributor.otherKristin Connorsen_US
dc.date.accessioned2014-06-02T18:36:38Z
dc.date.available2014-06-02T18:36:38Z
dc.date.copyright2014
dc.date.issued2014-06-02
dc.identifier.urihttp://hdl.handle.net/2104/8993
dc.description.abstractEnvironmental and human health implications of endocrine disrupting chemicals (EDCs), particularly xenoestrogens, have received extensive study. Multiple in vitro and in vivo techniques have been developed to assess estrogenicity. However, the relative sensitivity of these approaches and agreement of their conclusions remain inconclusive. As little to no toxicity data exist for a vast number of compounds, the U.S. Environmental Protection Agency (USEPA) created the ToxCast program to prioritize chemicals requiring additional toxicity information with high throughput screening assays. In addition, the Endocrine Disruptor Screening Program plans to use ToxCast data for identifying potential EDCs, and multiple assays pertain to endocrine disruption, particularly estrogenicity. Probabilistic Hazard Assessment (PHA) approaches, such as chemical toxicity distributions, can be used to measure the relative sensitivities of these assays by predicting the likelihood of chemical classes eliciting specific toxicities at or above environmentally relevant concentrations. The PHA in this study examined the comparative sensitivity of 19 assays for estrogen agonists representing a diverse group compounds from USEPA’s ToxCast dataset and noted considerations for assay selection. Overall, these assays had various levels of consistency, and reporter gene assays were among more sensitive designs. ToxCast estrogen agonist assays also had a low probability of detecting compounds below an E2 threshold for the MCF-7 human breast ademocarcinoma proliferation assay, which suggests the relative sensitivity of ToxCast estrogen agonist assays is lower than other in vitro models.en_US
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.subjectEnvironmental hazard assessment.en_US
dc.subjectComparative toxicology.en_US
dc.subjectChemical toxicity distributions.en_US
dc.subjectToxCast.en_US
dc.subjectTox21.en_US
dc.subjectEndocrine disruption.en_US
dc.subjectEstrogen agonist.en_US
dc.subjectThresholds of toxicological concern.en_US
dc.titleEmploying Probabilistic Hazard Assessment Approaches to Compare Sensitivity of ToxCast Estrogen Agonist Assaysen_US
dc.typeThesisen_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 3/2/2017.
dc.contributor.departmentEnvironmental Health Science.en_US
dc.contributor.schoolsHonors College.en_US


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