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    Synthesis and evaluation of 8-substituted adenine derivatives as toll-like receptor 7 agonists.

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    SEIFERT-THESIS-2015.pdf (2.479Mb)
    Zacharie_Seifert_CopyrightandAvailabilityform.pdf (20.88Kb)
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    Access changed 1/31/18.
    Date
    2015-04-08
    Author
    Seifert, Zacharie J. 1985-
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    Abstract
    Toll-like receptors (TLRs) are immune cell receptors that have the ability to recognize microbial pathogens and trigger innate immune responses. Research into TLR7 agonists is of specific interest because they can induce interferon (IFN) production without producing proinflammatory responses. In an ongoing study to synthesize small molecules that act as TLR7 agonists, several 9-benzyl-2-butoxyadenine derivatives with various substitutions at the 8-position have been prepared through a multi-step synthetic route. Utilizing the 8-bromoadenine derivative, both amine and thiol substitutions were performed. The 8-thioadenine derivative was then used to perform nucleophilic substitutions of numerous alkyl halides. These compounds were functionalized for their conjugation to a protein with the use of a protein linker while maintaining immune stimulatory activity.
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    http://hdl.handle.net/2104/9323
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    Copyright © Baylor® University All rights reserved. Legal Disclosures.
    Baylor University Waco, Texas 76798 1-800-BAYLOR-U
    Baylor University Libraries | One Bear Place #97148 | Waco, TX 76798-7148 | 254.710.2112 | Contact: libraryquestions@baylor.edu
    If you find any errors in content, please contact librarywebmaster@baylor.edu
    DSpace software copyright © 2002-2016  DuraSpace
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