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dc.contributor.advisorLee, Myeongwoo.
dc.creatorWu, Jing, 1990-
dc.date.accessioned2015-09-04T13:52:16Z
dc.date.available2015-09-04T13:52:16Z
dc.date.created2015-08
dc.date.issued2015-08-03
dc.date.submittedAugust 2015
dc.identifier.urihttp://hdl.handle.net/2104/9472
dc.description.abstractCaenorhabditis elegans provides a convenient tool to study host-pathogen interactions. In my research, I exposed worms with Staphylococcus aureus, the commensal bacteria that can utilize virulence factors to cause diseases in human. S. aureus infection caused egg-laying defect in C. elegans, which was characterized as the incapability to produce fertilized eggs and the difficulty in expelling eggs. Biofilm formed by S. aureus was confirmed to play a role in inducing the defect. Besides, part of the research was dedicated to isolate small molecules secreted by S. aureus and grow C. elegans in its mixture. Severe egg-laying defect was observed in worms under this situation, indicating the potential roles small molecules of S. aureus might be playing in C. elegans egg-laying. The defect could be alleviated by either placing worms back to a normal condition not long after the infection took place, or by providing worms with the neurotransmitter serotonin.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectC. elegans. S. aureus. Egg-laying.
dc.titleStapylococcus aureus infection modulates the egg-laying behavior of the nematode Caenorhabditis elegans.
dc.typeThesis
dc.rights.accessrightsWorldwide access
dc.rights.accessrightsAccess changed 12/5/17
dc.type.materialtext
thesis.degree.nameM.S.
thesis.degree.departmentBaylor University. Dept. of Biology.
thesis.degree.grantorBaylor University
thesis.degree.levelMasters
dc.date.updated2015-09-04T13:52:16Z
local.embargo.lift2017-08-01
local.embargo.terms2017-08-01


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