Comparison of Microbial Pathways in a Mouse Model with Cancer Cachexia and a Healthy Control




Brummel, Alea

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In the United States, colorectal cancer (CRC) is the third most diagnosed cancer in both men and women with over 106,000 new cases of colon and over 46,000 new cases of rectal cancer in 2023 alone. Due to increased screening and diagnostic methods for CRC, the overall incidence and mortality of CRC has been decreasing. However, CRC cases have significantly and alarmingly increased in people 50 years and younger, with a predicted increased incidence of CRC for people aged 20-34 years old by 90% for colon cancer and 124% for rectal cancer by 2030. The gut microbiome is known to have a direct link to CRC as well as other wasting disorders including cachexia and Kwashiorkor. In a mouse model with cancer cachexia, the metabolic pathways between healthy mice and cachexic mice were compared. Metabolic pathways were analyzed using the software PICRUSt and significant differences in metabolic pathways were found between control and cachexic mice.