Serotonin Regulation Of Intermittent And Continuous Alcohol Drinking In Male And Female C57BL/6J Mice With Systemic SB242084 And Buspirone
This study aimed to assess the therapeutic potentials of novel serotonergic compounds in treating alcohol use disorder by investigating the effects of SB242084 and buspirone on intermittent and continuous alcohol consumption in male and female C57BL/6J mice. Mice were given intraperitoneal injections of 0.3, 1, 3 mg/kg SB242084 or 1, 3, 10 mg/kg buspirone, and subsequent alcohol and water consumption were measured. SB242084 dose-dependently attenuated alcohol drinking for intermittent alcohol drinking in male mice but did not significantly alter alcohol drinking in mice given continuous access. In comparison, buspirone suppressed intermittent and continuous alcohol drinking in both males and females but also reduced distance traveled in the open field test. Observed differences in responses to SB242084 between drinking groups may imply differing neural mechanisms between heavy and continuous drinking driven by serotonin. These findings suggest the therapeutic potential of compounds blocking the 5-HT2C receptor for alcohol use disorders.