Total Synthesis of (±)-Dracocephalone A
In 2003, the Uchiyama group isolated dracocephalone A along with three other icetexane diterpenes. Evidence suggests that it possesses mild trypanocidal activity against Chagas disease. The first total synthesis of (±)-dracocephalone A is described. The synthesis involves 8 steps from two previously known molecules. The key transformation includes intramolecular Michael addition and a Suárez oxidation to assemble a tetrahydrofuran ring.