The Relationship Between Diet, the Gut Microbiome, and Cancer Immunotherapy Response and the Implications for Food-Insecure Cancer Patients

Date

2023

Authors

Jung, Alison

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Abstract

Diet significantly shapes human gut microbial composition and diversity. In recent years, research has emerged surrounding the influence of the diet and the gut microbiome on cancer immunotherapy response. Given that food insecurity induces poor dietary quality and malnutrition, there is a lack of research on the effects of food insecurity on the gut microbiome, and thus its impact on immunotherapy outcomes for food-insecure cancer patients. Scientific articles were reviewed and synthesized in order to investigate the relationship between diet, the gut microbiome, and cancer immunotherapy response. Dietary fiber, omega-3 intake, Ruminococcaceae, and Akkermansia muciniphila were among those identified as crucial dietary and microbial factors in facilitating optimal anti-tumor immunotherapy response. Articles studying the effects of food insecurity in the gut microbiome was also reviewed. Potential mechanisms for the interplay between the identified dietary and microbial factors and immunotherapy response were discussed, and areas for further research were proposed.

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Keywords

Diet., Gut microbiome., Cancer immunotherapy., Food insecurity.

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