A vitamin D enriched diet attenuates sex-specific behavioral deficits in the NS-Pten knockout mouse.

dc.contributor.advisorLugo, Joaquin N.
dc.creatorWomble, Paige Deann, 1995-
dc.date.accessioned2020-11-05T15:02:44Z
dc.date.available2020-11-05T15:02:44Z
dc.date.created2020-08
dc.date.issued2020-06-17
dc.date.submittedAugust 2020
dc.date.updated2020-11-05T15:02:45Z
dc.description.abstractIndividuals who experience recurrent spontaneous seizures are at a high risk for bone fractures as well as an increased likelihood of a comorbid diagnosis of Autism spectrum disorder. Additionally, individuals with epilepsy could have vitamin D deficiencies. The neural subset-specific (NS) Pten knockout (KO) mouse has shown autistic-like deficits and has a lower bone mineral density. We examined the effect of a vitamin D enriched diet in the NS-Pten KO mouse. Results indicated that a vitamin D diet attenuated altered activity levels in male NS-Pten KO mice. NS-Pten KO animals exhibited a reduction in sociability, however in male wildtype mice, vitamin D increased sociability. There was a significant effect of genotype and death, and between diet and death, finding that only CTL NS-Pten KO animals died. Overall, these findings suggest that a vitamin D enriched diet had a significant impact on the behavioral phenotype and survivability of NS-Pten KO mice.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2104/11095
dc.language.isoen
dc.rights.accessrightsNo access – contact librarywebmaster@baylor.edu
dc.subjectEpilepsy. Autism. Bone density. Seizures. Fortified diet.
dc.titleA vitamin D enriched diet attenuates sex-specific behavioral deficits in the NS-Pten knockout mouse.
dc.typeThesis
dc.type.materialtext
local.embargo.lift2025-08-01
local.embargo.terms2025-08-01
thesis.degree.departmentBaylor University. Dept. of Psychology & Neuroscience.
thesis.degree.grantorBaylor University
thesis.degree.levelMasters
thesis.degree.nameM.A.

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