PKCγ expression in adolescent and adult rats : evidence for a cerebellar mechanism underlying age-dependent motor impairments produced by acute ethanol.

dc.contributor.advisorDiaz-Granados, Jaime L.
dc.contributor.advisorMatthews, Douglas B.
dc.contributor.authorVan Skike, Candice E.
dc.contributor.departmentPsychology and Neuroscience.en
dc.contributor.otherBaylor University. Dept. of Psychology and Neuroscience.en
dc.date.accessioned2011-05-12T15:52:08Z
dc.date.available2011-05-12T15:52:08Z
dc.date.copyright2011-05
dc.date.issued2010-12
dc.description.abstractAdolescents are less sensitive to ethanol-induced motor impairments compared to adults; however, a definitive mechanism underlying this difference has not been identified. Compared to wild-type littermates, PKCγ knock-out mice exhibit reduced motor sensitivity to ethanol; it is plausible that adolescent rats also have reduced PKCγ expression in brain regions responsible for motor function, specifically the cerebellum and cortex. Reduced PKCγ expression in these regions may govern the age-dependent motor impairments produced by ethanol. The current study analyzed membrane-bound PKCγ expression in adolescent and adult rats 40 minutes after an acute ethanol or saline injection. Western blot analysis indicates adolescent rats have reduced PKCγ expression in the cerebellum and cortex compared to adults. It is concluded that PKCγ expression may be part of a larger mechanism regulating the age-dependent motor impairments produced by acute ethanol administration.en
dc.description.degreeM.A.en
dc.description.statementofresponsibilityby Candice E. Van Skike.en
dc.format.extent132276 bytes
dc.format.extent160689 bytes
dc.format.extent382296 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.identifier.citationVan Skike, C. E., Botta, P., Chin, V. S., Tokunaga, S., McDaniel, J. M., Venard, J., Diaz-Granados, J. L., Valenzuela, C. F., Matthews, D. B. "Behavioral effects of ethanol in cerebellum are age dependent : potential system and molecular mechanisms." Alcoholism : Clinical and Experimental Research 32, 12 (2010): 2070-2080.en
dc.identifier.urihttp://hdl.handle.net/2104/8175
dc.language.isoen_USen
dc.publisherJohn Wiley & Sons.en
dc.rightsBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.en
dc.rights.accessrightsWorldwide accessen
dc.subjectAdolescence.en
dc.subjectAlcohol.en
dc.subjectProtein Kinase C.en
dc.subjectEthanol-induced motor impairments.en
dc.subjectCerebellum.en
dc.titlePKCγ expression in adolescent and adult rats : evidence for a cerebellar mechanism underlying age-dependent motor impairments produced by acute ethanol.en
dc.typeThesisen

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