An Investigation of Wheel Running in Models of Cancer-Related Fatigue




Earagolla, Sindhuja

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Fatigue is an extreme feeling of tiredness, often described as being unable to function at normal capacity. Cancer-related fatigue (CRF) is more severe and persistent than everyday fatigue, causing disruption in all aspects of quality of life. There are currently no standard medical tests to assess fatigue. Comparing current voluntary activity levels to baseline activity levels helps clinicians assess the changes responsible for the observed fatigue. In a murine model, this is characterized by wheel running. This study was conducted to determine the locus of change in fatigue by assessing wheel running across three different models. In the cisplatin model, there was a significant difference in running speed, suggesting that an increase in inflammatory stimuli potentially disrupted the dopamine pathway, leading to a lack of motivation and motor activity. In the tumor model, there was no significant difference found in running speed, potentially due to tumor growth blocking or slowing action potentials, leading to peripheral fatigue in skeletal muscle tissue. Finally, in the early stress model, a significant sex difference was found where females had a greater running speed, time, and distance. This could potentially be due to exercise modulating behavior as a treatment for the experienced stress. Further research has to be conducted to confirm these theories and identify underlying factors for the locus of change of fatigue.



Cancer-Related Fatigue