Effect of Oncomodulin on Afferent Inner Hair Cell and Efferent Outer Hair Cell Synaptopathy

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dc.contributor.advisorSimmons, Dwayne
dc.contributor.authorThompson, Pierce
dc.contributor.departmentBiology.en_US
dc.date.accessioned2022-05-20T18:57:36Z
dc.date.available2022-05-20T18:57:36Z
dc.date.copyright2022-05-05
dc.date.issued2022-05-20
dc.description.abstractInner hair cells (IHCs) are a type of specialized sensory cell which converts the pressure gradient of the endolymph into an interpretable signal, allowing for hearing. However, there is another type of sensory cell crucial for hearing: outer hair cells (OHCs). OHCs amplify basilar membrane motion through the movement of prestin, a voltage-sensitive motor protein, resonating with its respective tonotopic frequency. The medial olivocochlear (MOC) system is part of the auditory system which synapses on OHCs with cholinergic receptors, acting antagonistically to prestin by hyperpolarizing the cell, resulting in cochlear acoustic protection through a calcium dependent mechanism. Loss of function of the MOC system has been shown to precede progression of age-related sensory deficits, but the correlation between the loss of function of the MOC system and OHC vitality is yet to be examined. This paper will examine the correlation between OHC vitality, efferent MOC synapses, and afferent glutaminergic synapses.en_US
dc.identifier.urihttps://hdl.handle.net/2104/11885
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.subjectBiologyen_US
dc.titleEffect of Oncomodulin on Afferent Inner Hair Cell and Efferent Outer Hair Cell Synaptopathyen_US
dc.typeThesisen_US

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