Prenatal Stress Increases Both Learned and Unlearned Fear in Adult Rats

dc.contributor.advisorKeele, N. Bradley.
dc.contributor.authorMeyer, Melissa
dc.contributor.departmentUniversity Scholars.en_US
dc.contributor.otherBaylor University.en_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2014-05-02T22:51:59Z
dc.date.available2014-05-02T22:51:59Z
dc.date.copyright2014
dc.date.issued2014-05-02
dc.description.abstractThe amygdala is critical in generating the emotion of fear. Exposure to stress during prenatal development is associated with changes in fear- and anxiety-like behavior. To examine the influence of prenatal stress on emotional behavior in adults, offspring of prenatal-stressed (PNS) and unstressed control (USC) dams were evaluated on behavioral tests (one pup per litter on each), including fear-potentiated startle, elevated plus maze, open field test, and three-chambered social approach. Fear-potentiated startle indicated that USC rats had less conditioned fear than PNS rats, suggesting higher learned fear in the PNS group. The elevated plus maze indicated that USC rats had a higher preference for the open arms than PNS rats, suggesting a tendency toward increased anxiety-like behavior in the PNS group. The open field test showed no difference in locomotor behavior between USC and PNS rats. This project shed light on the impact that early life experience has on adult behavior relevant to psychopathologies such as mood and anxiety disorders.en_US
dc.identifier.urihttp://hdl.handle.net/2104/8986
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.subjectNeuroscience.en_US
dc.subjectPsychology.en_US
dc.subjectPrenatal stress.en_US
dc.subjectLearned fear.en_US
dc.subjectUnlearned fear.en_US
dc.subjectAnxiety.en_US
dc.subjectFear potentiated startle.en_US
dc.subjectElevated plus maze.en_US
dc.subjectOpen field test.en_US
dc.subjectThree-chambered social approach.en_US
dc.subjectSociability.en_US
dc.subjectPreference for social novelty.en_US
dc.subjectAmygdala.en_US
dc.subjectHPA axis.en_US
dc.subjectNeural dysfunction.en_US
dc.titlePrenatal Stress Increases Both Learned and Unlearned Fear in Adult Ratsen_US
dc.typeThesisen_US

Files

Original bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
melissa_meyer_ThesisCopyrightAvailability.pdf
Size:
1.39 MB
Format:
Adobe Portable Document Format
Description:
Permissions Form
Loading...
Thumbnail Image
Name:
melissa_meyer PDFA HonorsThesis.pdf
Size:
682.49 KB
Format:
Adobe Portable Document Format
Description:
Thesis

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.87 KB
Format:
Item-specific license agreed upon to submission
Description: