Designing Novel Anticancer Drug Leads Based on the Natural Products Gracilin A and Pateamine A

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dc.contributor.advisorRomo, Daniel
dc.contributor.authorJones, Dalton
dc.contributor.departmentBiology.en_US
dc.date.accessioned2021-05-20T16:31:13Z
dc.date.available2021-05-20T16:31:13Z
dc.date.copyright2021
dc.date.issued2021-05-20
dc.description.abstractNatural products form the foundation of many different small molecules used as drugs. Molecular modeling is a key tool in the early stages of drug development that helps to identify derivatives of natural products that might be promising drug leads. This thesis uses molecular modeling and computational studies to explore the potential of natural products gracilin A and pateamine A as the foundation of future anticancer drug leads. I first explore the role of specific target proteins in the body with a focus on cancer cells, then analyze the binding sites of the target proteins in a three-dimensional space with a focus on their compatibility with the natural products. Finally, I perform a series of docking simulations to identify promising compounds for future synthesis and testing in biological assays.en_US
dc.identifier.urihttps://hdl.handle.net/2104/11285
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 9/21/23.
dc.titleDesigning Novel Anticancer Drug Leads Based on the Natural Products Gracilin A and Pateamine Aen_US
dc.typeThesisen_US

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