Taurine depletion in adolescent mice and implications for ethanol withdrawal-induced anxiety.

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dc.contributor.advisorDiaz-Granados, Jaime L.
dc.contributor.authorHelfand, Rebecca S.
dc.contributor.departmentPsychology and Neuroscience.en
dc.contributor.otherBaylor University. Dept. of Psychology and Neuroscience.en
dc.date.accessioned2007-12-03T18:43:56Z
dc.date.available2007-12-03T18:43:56Z
dc.date.copyright2007
dc.date.issued2007-12-03T18:43:56Z
dc.descriptionIncludes bibliographical references (p. 53-74).en
dc.description.abstractAdolescents exhibit few negative neurobehavioral effects of ethanol withdrawal and have higher levels of taurine, an inhibitory amino acid, than adults. Given taurine’s neuroprotective role and abundance during adolescence, it is possible that taurine is acting to attenuate adolescents’ negative response to ethanol withdrawal. The current study examined the effects of 7 days of taurine depletion with GES on withdrawal-induced anxiety as measured on the elevated plus maze (EPM) and plasma corticosterone levels. Plasma corticosterone levels were significantly higher in the GES and ethanol exposed group than any of the other groups. The results indicate that while taurine depletion did not decrease open arm time as expected, the combination of exposure to GES and ethanol significantly increased plasma corticosterone levels. The major finding of this study is that the depletion of taurine during adolescence affected biochemical but not behavioral measures of anxiety further implicating taurine’s protective role during ethanol withdrawal.en
dc.description.degreeM.A.en
dc.description.statementofresponsibilityby Rebecca S. Helfand.en
dc.format.extentviii, 74 : ill.en
dc.format.extent154740 bytes
dc.format.extent495094 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/2104/5059
dc.language.isoen_USen
dc.rightsBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.en
dc.rights.accessrightsWorldwide accessen
dc.subjectTaurine.en
dc.subjectTaurine -- Physiological effect.en
dc.subjectAlcohol -- Physiological effect.en
dc.titleTaurine depletion in adolescent mice and implications for ethanol withdrawal-induced anxiety.en
dc.typeThesisen
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