Markers of bioenergetic changes in liver tissue from obese and lean tumor-bearing mice.

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dc.contributor.advisorWiggs, Michael P.
dc.creatorRodriguez, Rebecca F., 1999-
dc.creator.orcid0009-0007-0377-625X
dc.date.accessioned2024-07-17T14:14:57Z
dc.date.available2024-07-17T14:14:57Z
dc.date.created2023-08
dc.date.issued2023-08
dc.date.submittedAugust 2023
dc.date.updated2024-07-17T14:14:57Z
dc.description.abstractCancer cachexia is associated with the decreased quality of life and has potential to dysregulate whole-body metabolism. The liver is highly understudied in the literature yet is a prominent figure in whole-body metabolic regulation. The purpose of this study was to examine changes in biomarkers of bioenergetics in liver tissue of lean and obese cachectic mice. Mature male mice were fed chow (lean) or 12 weeks of high fat diet (obese). Following the diet intervention, groups were further divided into PBS control or LLC tumor-bearing mice. Tissues were collected 25 days post-injection. Tumor progression in obese mice was correlated with increased expression of lipid metabolism genes, no difference in expression of glucose metabolism genes when compared to the PBS group, and no difference in expression of mitochondrial biogenesis genes when compared to the PBS group.
dc.format.mimetypeapplication/pdf
dc.identifier.uri
dc.identifier.urihttps://hdl.handle.net/2104/12841
dc.language.isoEnglish
dc.rights.accessrightsNo access – contact librarywebmaster@baylor.edu
dc.titleMarkers of bioenergetic changes in liver tissue from obese and lean tumor-bearing mice.
dc.typeThesis
dc.type.materialtext
local.embargo.lift2025-08-01
local.embargo.terms2025-08-01
thesis.degree.departmentBaylor University. Dept. of Health, Human Performance & Recreation.
thesis.degree.grantorBaylor University
thesis.degree.nameM.S.
thesis.degree.programExercise Physiology
thesis.degree.schoolBaylor University

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